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Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size. [PDF]

Am J Physiol Cell Physiol
Baehr LM, Oliveira de Sousa LG, Goodman CA, Sharples AP, Waddell DS, Bodine SC, Hughes DC.   +6 more
europepmc   +1 more source

The E3 ubiquitin ligases ATL31/6 mediate TMK1 degradation to downregulate TMK1-dependent auxin signaling in Arabidopsis. [PDF]

Plant Commun
Zhou Y, Chen K, Yin J, Dong C, Huang X, Wang Y, Lin W, Lu D.   +7 more
europepmc   +1 more source

UBR5: A New Player in Protein Quality Control for Skeletal Muscle Growth and Remodeling. [PDF]

Exerc Sport Sci Rev
Hughes DC, Bodine SC.
europepmc   +1 more source

Advancing PROTAC Discovery Through Artificial Intelligence: Opportunities, Challenges, and Future Directions. [PDF]

Pharmaceuticals (Basel)
Park KS, Jeon M.
europepmc   +1 more source

Ubiquitin-centered post-translational modification crosstalk orchestrates tumor immunity and immunotherapy response. [PDF]

Exp Hematol Oncol
Qiao K, Wu L, Yang L, Liu M, Jiang C, Chen Y, Zhang Z, Yu J, Wei D, Xu Y.   +9 more
europepmc   +1 more source

Updates on the role of TRIM proteins in AIDS: molecular mechanisms and potential for interventions. [PDF]

Front Immunol
Chen J, Chen S, Xu Y, Wang X, Jiang M.
europepmc   +1 more source

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RNA Ligases

Current Protocols in Molecular Biology, 2008
AbstractT4 RNA ligase 1 catalyzes the ATP‐dependent covalent joining of single‐stranded 5′‐phosphoryl termini of DNA or RNA to single‐stranded 3′‐hydroxyl termini of DNA or RNA. T4 RNA ligase 2 also catalyzes the joining of a 3′‐hydroxyl terminus of RNA to a 5′‐phosphorylated RNA or DNA; unlike T4 RNA ligase 1, this enzyme prefers double‐stranded ...
Nicole M, Nichols, Stanley, Tabor, Larry A, McReynolds   +2 more
openaire   +2 more sources

Ligase IV syndrome

European Journal of Medical Genetics, 2009
Ligase IV (LIG4) syndrome belongs to the group of hereditary disorders associated with impaired DNA damage response mechanisms. Subjects affected with this rare autosomal recessive disease exhibit microcephaly, unusual facial features, growth retardation, developmental delay, skin anomalies, and are typically pancytopenic.
Dimitry A, Chistiakov, Natalia V, Voronova, Alexander P, Chistiakov   +2 more
openaire   +2 more sources