Results 11 to 20 of about 120,350 (347)

Identification of a novel motif in DNA ligases exemplified by DNA ligase IV [PDF]

open access: yesDNA Repair, 2006
DNA ligase IV is an essential protein that functions in DNA non-homologous end-joining, the major mechanism that rejoins DNA double-strand breaks in mammalian cells. LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead
Doherty, Aidan J   +5 more
core   +5 more sources

From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease

open access: yesCells, 2022
The ubiquitin–proteasome system is of fundamental importance in all fields of biology due to its impact on proteostasis and in regulating cellular processes.
Valérie C. Cabana, Marc P. Lussier
doaj   +1 more source

Ligation and Ligases [PDF]

open access: yesCold Spring Harbor Protocols, 2019
DNA ligases are used chiefly to create novel combinations of nucleic acid molecules and to attach them to vectors before molecular cloning. They are either of bacterial origin or bacteriophage encoded and have different properties, as discussed here.
Michael R. Green, Joseph Sambrook
openaire   +3 more sources

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

open access: yesClinical and Translational Medicine, 2023
Ubiquitination is one of the most important post‐translational modifications which plays a significant role in conserving the homeostasis of cellular proteins.
Chibuzo Sampson   +6 more
doaj   +1 more source

Ubiquitin ligases and beyond [PDF]

open access: yesBMC Biology, 2012
In a review published in 2004 [1] and that still repays reading today, Cecile Pickart traced the evolution of research on ubiquitination from its origins in the proteasomal degradation of proteins through the revelation that it has a central role in cell cycle regulation and the recognition of regulatory roles for ubiquitin in intracellular membrane ...
Đikić, Ivan, Robertson, Miranda
openaire   +6 more sources

The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer

open access: yesCell Death Discovery, 2023
To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve the outcome of CRC patients.
Jie Chen   +8 more
doaj   +1 more source

Thermostable DNA ligases from hyperthermophiles in biotechnology

open access: yesFrontiers in Microbiology, 2023
DNA ligase is an important enzyme ubiquitous in all three kingdoms of life that can ligate DNA strands, thus playing essential roles in DNA replication, repair and recombination in vivo.
Jingru Shi   +3 more
doaj   +1 more source

The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy

open access: yesFrontiers in Immunology, 2023
Bladder cancer is one of the common malignant urothelial tumors. Post-translational modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, have been revealed to participate in bladder cancer initiation and ...
Xuemei Wang   +4 more
doaj   +1 more source

Comprehensive analysis of the expression and prognosis for RBR E3 ubiquitin ligases in lung adenocarcinoma

open access: yesThoracic Cancer, 2022
Background Lung adenocarcinoma (LUAD) is the most common subtype of non‐small cell lung cancer and has a poor prognosis. RBR E3 ubiquitin ligases are a special class of E3 ubiquitin ligases which contain three zinc‐bing domains that catalyze ubiquitin to
Hao Ding   +12 more
doaj   +1 more source

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]

open access: yes, 2012
Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone   +2 more
core   +2 more sources

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