Results 191 to 200 of about 86,842 (296)
Promiscuous protein biotinylation by Escherichia coli biotin protein ligase [PDF]
, 2004 Eunjoo Choi‐Rhee +2 more
openalex +1 more source
Advanced Science, EarlyView.In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen +15 more
wiley +1 more source
Small-molecule degron mimetics for targeted protein degradation. [PDF]
Essays BiochemLiu X.
europepmc +1 more source
Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination [PDF]
, 2013 Bridgid E. Hast +7 more
openalex +1 more source
Advanced Science, EarlyView.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
Interplay between ubiquitination and ADP-ribosylation and the case of dual modification ADPr-Ub. [PDF]
Essays BiochemZhu K +4 more
europepmc +1 more source
Advanced Science, EarlyView.This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao +10 more
wiley +1 more source