Results 201 to 210 of about 143,768 (336)

Small-molecule degron mimetics for targeted protein degradation. [PDF]

Essays Biochem
Liu X.
europepmc   +1 more source

PIASx Is a MEF2 SUMO E3 Ligase That Promotes Postsynaptic Dendritic Morphogenesis [PDF]

, 2007
Aryaman Shalizi, Parizad M. Bilimoria, Judith Stegmüller, Brice Gaudillière, Yue Yang, Ke Shuai, Azad Bonni   +6 more
openalex   +1 more source

PACS‐2 Mitigates NPSC Apoptosis and Intervertebral Disc Degeneration by Preserving MAM Integrity via the SP1/LRRK2/Mfn2 Axis

Advanced Science, EarlyView.
This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang, Jiaqi Wang, Chenhao Zhao, Qiuwei Li, Zhigang Zhang, Huaqing Zhang, Chongyu Jia, Luping Zhou, Yanxin Wang, Yu Chen, Kaixuan Li, Xu Yan, Jie Fang, Haibao Wang, Dandan Wang, Pingping Su, Jingyu Zhang, Zhiwei Chen, Renjie Zhang, Cailiang Shen   +19 more
wiley   +1 more source

Exploring the ubiquitination regulatory network: opening new perspectives for rheumatoid arthritis therapy. [PDF]

Ann Med
Wang F, Liu J, Wen J, Sun Y, He M.
europepmc   +1 more source

Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome [PDF]

, 2008
Suchithra Menon, Tomohiko Tsuge, Naoshi Dohmae, Koji Takio, Ning Wei   +4 more
openalex   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Interplay between ubiquitination and ADP-ribosylation and the case of dual modification ADPr-Ub. [PDF]

Essays Biochem
Zhu K, Chatrin C, Smith R, Ahel D, Ahel I.   +4 more
europepmc   +1 more source

E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis [PDF]

, 2016
Leena Ackermann, Michael J. Schell, Wojciech Pokrzywa, Éva Kevei, Anton Gartner, Björn Schumacher, Thorsten Hoppe   +6 more
openalex   +1 more source

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, EarlyView.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

Role of Ubiquitin-regulated EMT in Cancer Metastasis and Chemoresistance. [PDF]

Int J Biol Sci
Xiao S, Tian L, Gan X, Xu X, Liao M, Song D, Yu Y, Qin W, Zhang R, Lyu H, Guo D, Zhang Q, Chen XZ, Zhou C, Tang J.   +14 more
europepmc   +1 more source