Results 261 to 270 of about 143,768 (336)

PBLD Orchestrates the STING‐Mediated Antiviral Immune Response and Autoimmune Diseases

Advanced Science, EarlyView.
During viral infection, PBLD expression is downregulated, thereby subverting host antiviral defenses and promoting viral replication. This study identifies PBLD as a positive regulator of STING‐induced type I interferon activation and delineated the molecular network underlying PBLD‐mediated antiviral immunity and autoimmune pathogenesis, highlighting ...
Peili Hou, Hongchao Zhu, Xiaonan Sun, Ni Zhang, Song Wang, Xuexing Zheng, Xiaoyun Wang, Yueyue Feng, Fuzhen Zhang, Xingyu Li, Rui Li, Xiaomeng Wang, Yuanyuan Han, Jun Wang, Chuanhong Wang, Xiaoyang Yao, Hongmei Wang, Hongbin He   +17 more
wiley   +1 more source

A novel prognostic model based on endoplasmic reticulum stress-associated E3 ligases and deubiquitinating enzymes in hepatocellular carcinoma. [PDF]

Transl Cancer Res
Zhong C, Liu Y, Hu K, Yin D.
europepmc   +1 more source

AP2M1 Amplification Orchestrates Notch‐Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients

Advanced Science, EarlyView.
The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee, Eun Kyoung Kim, Hee Young Ju, Chae Rin Lee, Soyul Ahn, Eun‐Sun Kim, Kyungjae Myung, Won Kyu Kim, Su‐Yeon Cho, Yujin Kwon, Dokyoung Kim, Yeuni Yu, Eun Jung Kwon, Hyomin Kim, Seong Ik Mun, Dong Min Lim, Kihun Kim, Hye Jin Heo, Seung Eun Baek, Sun Young Lee, Hyunsoo Cho, Eun Young Choi, Tae Sik Goh, Ninib Baryawno, Dongjun Lee, Ki Sun Jung, Keon Hee Yoo, Chang‐Kyu Oh, Yun Hak Kim   +28 more
wiley   +1 more source

The ubiquitin-proteasome system in circadian regulation. [PDF]

Front Neurosci
Costanzo KM, Prifti MV, Todi SV, Mohan RD.   +3 more
europepmc   +1 more source

DNA Ligase [PDF]

, 2020
openaire   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

The multifaceted roles of E3 ubiquitin ligases in osteoarthritis. [PDF]

Front Cell Dev Biol
Jin Z, Zhu Z, Chen J, Jing X, Tan J, Zeng J.   +5 more
europepmc   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

The RING-finger domain of Arabidopsis RMR functions as an E3 ligase essential for post-Golgi trafficking. [PDF]

J Biol Chem
Chen S, Zeng Y, Wong HY, Chen Y, Yang L, Luo F, Gao C, Jiang L, Wong KB.   +8 more
europepmc   +1 more source

Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF‐1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression

Advanced Science, EarlyView.
Cancer cells drive adjacent adipose tissue to release fatty acids by secreting CCL2, which activates PPARα‐dependent lipolysis. The resulting fatty acid influx amplifies HIF‐1α/CCL2 signaling, establishing a positive feedback loop that fuels tumor growth.
Jeong‐Eun Yun, Jieun Seo, Jiwon Koh, Seock‐Ah Im, Ki Yong Hong, Yeseon Son, Do‐Won Jeong, Junji Fukuda, Jong‐Wan Park, Yang‐Sook Chun   +9 more
wiley   +1 more source