Results 291 to 300 of about 125,351 (338)
Advanced Science, EarlyView.Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang +12 more
wiley +1 more source
The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagy. [PDF]
Essays BiochemDubiel W, Dubiel D.
europepmc +1 more source
Traceless Regulation of Genetic Circuitry
Advanced Science, EarlyView.Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley +1 more source
The Roles of E3 Ubiquitin Ligases in Cerebral Ischemia-Reperfusion Injury. [PDF]
Int J Mol SciLi M, Yu X, Liu Q, Fang Z, Wang H.
europepmc +1 more source
Ubiquitination in macrophage plasticity: from inflammatory to immunometabolic pathways. [PDF]
Front ImmunolLiu J, Paolino M.
europepmc +1 more source
Pathogenic roles of immunoproteasomes in fibrosis. [PDF]
Essays BiochemKim S, Park SH, Lee MJ.
europepmc +1 more source
Regulation via compartmentation: adaptive localization of the proteasome under stress. [PDF]
Biochem Soc TransCiechanover A, Livneh I.
europepmc +1 more source
Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy. [PDF]
FEBS JTrejo-Cerro O +2 more
europepmc +1 more source