Results 101 to 110 of about 718,207 (427)

A Novel Cu²⁺ Quantitative Detection Nucleic Acid Biosensors Based on DNAzyme and “Blocker” Beacon

Foods, 2023
In this paper, a “turn-off” biosensor for detecting copper (II) ions based on Cu2+-dependent DNAzyme and a “blocker” beacon were developed. Upon the copper ion being added, the Cu2+-dependent DNAzyme substrate strand was irreversibly cleaved, thereby ...
Hanyue Zhang, Kai Dong, Shuna Xiang, Yingting Lin, Xiaoyan Cha, Ying Shang, Wentao Xu   +6 more
doaj   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Calculation of the Electronic Structure and Optical Absorption of the Ligated Magic-Size Clusters with Cd$_8$Se$_{13}$ Core [PDF]

arXiv, 2020
A series of the cadmium selenide magic size clusters with the cores of Cd$_8$Se$_{13}$ terminated with H- and N-containing ligands are calculated at the DFT level with different functionals and ECP basis sets. The optimum functional was selected on the basis of calculation for diatomic CdSe and other smallest clusters with available experimental data ...
arxiv  

Structure of a spliceosome remodelled for exon ligation

Nature, 2017
The spliceosome excises introns from pre-mRNAs in two sequential transesterifications—branching and exon ligation—catalysed at a single catalytic metal site in U6 small nuclear RNA (snRNA).
S. Fica, C. Oubridge, W. P. Galej, M. E. Wilkinson, X. Bai, A. Newman, K. Nagai   +6 more
semanticscholar   +1 more source

The peculiarities of morphological damages of the liver during obstructive cholestasis in clinic and experiment. [PDF]

Морфологія, 2007
The purpose of work was to study of the liver depending on blood level of bilirubine during obstructive cholestasis. 35 patients of 4 groups were examined: I - with the level of blood bilirubine lower 50 mM/l; II - 50-100 mM/l; III - 100-200 mM/l; IV ...
Gaydar Yu.A., Ostrovsky O.S., Radchik B.M., Kononov I.M.   +3 more
doaj  

Intensive Care Tactics for Reducing Gastrointestinal Bleeding in the Context of Portal Hypertension

Креативная хирургия и онкология, 2019
Introduction. Gastrointestinal bleeding is currently one of the most significant pathologies indicating lethality. Factors in the incidence of gastrointestinal bleeding include the spread of gastrointestinal diseases caused by eating disorders ...
A. Zh. Bayaliyeva, Ju. N. Yankovich, R. R. Nagimullin, V. R. Davydova   +3 more
doaj   +1 more source

The Role of mTOR and Injury in Developing Salispheres

Biomedicines, 2023
Salispheres are the representative primitive cells of salivary glands grown in vitro in a nonadherent system. In this study, we used the ligation model for salisphere isolation after seven days of obstruction of the main excretory duct of the ...
Rimah Saleem, Guy Carpenter
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Analysis of ligation and DNA binding by Escherichia coli DNA ligase (LigA). [PDF]

, 2005
NAD+-dependent DNA ligases are essential enzymes in bacteria, with the most widely studied of this class of enzymes being LigA from Escherichia coli. NAD+-dependent DNA ligases comprise several discrete structural domains, including a BRCT domain at the ...
Adam Wilkinson, Alexandra Bonner, Altschul, Andrew Hemmings, Andrew Smith, Baer, Bork, Brotz-Oesterhelt, Callebaut, Derbyshire, Dermody, Desmond Bullard, Doherty, Doherty, Doherty, Feng, Gajiwala, Georlette, Georlette, Glover, Gong, Grawunder, Guex, Gunther, Halligan, Heather Sayer, Herrmann, Huyton, Jeon, Joo, Kaczmarek, Kodama, Krishnan, Lavesa-Curto, Lee, Legrain, Lehman, Manuel Lavesa-Curto, Masson, Odell, Pascal, Richard Bowater, Sambrook, Shuman, Singleton, Sriskanda, Sriskanda, Sriskanda, Sriskanda, Subramanya, Timson, Timson, Wieland, Wilkinson, Wilkinson, Williams, Yamane, Yamane, Zhang, Zimmerman   +59 more
core   +1 more source

Induction of Myocardial Infarction in Experimental Animals: A Review [PDF]

Journal of Clinical and Diagnostic Research, 2018
Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientific research. This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involved ...
Syarifah Aisyah Syed Abd Halim, Norzana Abd Ghafar, Zakiah Jubri, Srijit Das   +3 more
doaj   +1 more source