Results 111 to 120 of about 88,762 (345)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Differential stability of bacterial photosynthetic apparatus of Rhodobacter alkalitolerans strain JA916T under alkaline and light environment

Frontiers in Microbiology
In purple bacteria, photosynthesis is performed by densely packed pigment-protein complexes, including the light-harvesting complexes known as RC-LH1 and LH2, with carotenoids to assist in the functioning of photosynthesis.
Mohammad Yusuf Zamal, Saikiran Madireddi, Nageswara Rao Mekala, Venkata Ramana Chintalapati, Rajagopal Subramanyam   +4 more
doaj   +1 more source

Light quantity affects the regulation of cell shape in Fremyella diplosiphon

Frontiers in Microbiology, 2012
In some cyanobacteria, the color or prevalent wavelengths of ambient light can impact the protein or pigment composition of the light-harvesting complexes. In some cases, light color or quality impacts cellular morphology.
Bagmi ePattanaik, Melissa J. Whitaker, Beronda L Montgomery   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

SYNTHESIS OF p-PHENYLENE VINYLENE DENDRONS & THEIR FUNCTIONALIZATION AND TESTING IN DYE-SENSITIZED SOLAR CELLS [PDF]

, 2013
The novel synthesis of p-phenylene vinylene dendrons utilizing a Horner-Wadsworth-Emmons based approach is described. The extended, linear π conjugation along all the dendron branches, a feature absent in most dendrimers used for light harvesting, was ...
Bell, Peter
core  

Quantum entanglement in photosynthetic light-harvesting complexes [PDF]

, 2010
Light harvesting components of photosynthetic organisms are complex, coupled, many-body quantum systems, in which electronic coherence has recently been shown to survive for relatively long time scales despite the decohering effects of their environments.
Mohan Sarovar, Whaley, K Birgitta, Ishizaki, Akihito, Graham R. Fleming, K. Birgitta Whaley, Akihito Ishizaki, Sarovar, Mohan, Fleming, Graham R   +7 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Three dimensional structure of the light-harvesting chlorophyll a/b protein complex from plant chloroplasts

, 2002
The light-harvesting chlorophyll a/b protein complex (LHC-II) is the major collector of solar energy in all plants and it binds about half of the chlorophyll in green plants.
Lamborghini, Matteo, Lamborghini, M.
core  

The Arabidopsis Thylakoid Protein PAM68 Is Required for Efficient D1 Biogenesis and Photosystem II Assembly [PDF]

, 2010
Photosystem II (PSII) is a multiprotein complex that functions as a light-driven water:plastoquinone oxidoreductase in photosynthesis. Assembly of PSII proceeds through a number of distinct intermediate states and requires auxiliary proteins.
Leister, D., Makarenko, Elina, Bernd Weisshaar, Jahns, P., Schünemann, Danja, Ute Armbruster, Nickelsen, Joerg, Rengstl, Birgit, Zuehlke, Jessica, Ruehle, T., Nickelsen, J., Jörg Nickelsen, Makarenko, E., Weisshaar, B., Rühle, Thilo, Kreller, Renate, Jessica Zühlke, Rengstl, B., Leister, Dario, Schuenemann, Danja, Renate Kreller, Schuenemann, D., Armbruster, U., Jahns, Peter, Ruehle, Thilo, Weisshaar, Bernd ; https://orcid.org/, Zuehlke, J., Peter Jahns, Birgit Rengstl, Dario Leister, Elina Makarenko, Kreller, R., Zühlke, Jessica, Nickelsen, Jörg, Armbruster, Ute, Danja Schünemann, Thilo Rühle, Weisshaar, Bernd   +37 more
core   +1 more source