Results 171 to 180 of about 104,392 (267)

Light-sheet fluorescence microscopy for the in vivo study of microtubule dynamics in the zebrafish embryo. [PDF]

Biomed Opt Express, 2021
Bernardello M, Marsal M, Gualda EJ, Loza-Alvarez P.   +3 more
europepmc   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Digital Brain Maps and Virtual Neuroscience: An Emerging Role for Light-Sheet Fluorescence Microscopy in Drug Development. [PDF]

Front Neurosci, 2022
Perens J, Hecksher-Sørensen J.
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Multimodal optical coherence tomography and two-photon light sheet fluorescence microscopy for embryo imaging. [PDF]

J Biomed Opt
Karim MM, Sun R, Khajavi B, Singh M, Ambekar YS, Schill AW, Aglyamov SR, Mayerich D, Larin KV.   +8 more
europepmc   +1 more source

Light sheet fluorescence microscopy for the investigation of blood-sucking arthropods dyed via artificial membrane feeding. [PDF]

Parasit Vectors, 2022
Ten Bosch L, Habedank B, Candeo A, Bassi A, Valentini G, Gerhard C.   +5 more
europepmc   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Illuminating Satellite Cells: Light Sheet Fluorescence Microscopy for 3D Imaging of Murine Skeletal Muscles Damaged by Ex Vivo Forced Eccentric Contraction. [PDF]

Microsc Res Tech
Garella R, Imbimbo E, Palmieri F, Tani A, Parigi M, Chellini F, La Contana A, Belmonte MM, Longhin A, Silvestri L, Sassoli C, Squecco R.   +11 more
europepmc   +1 more source

Erratum: Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publisher's note. [PDF]

Biomed Opt Express, 2022
Li C, Moatti A, Zhang X, Ghashghaei HT, Greenbaum A.   +4 more
europepmc   +1 more source

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source