Results 181 to 190 of about 5,336,418 (265)

Detaching Photosensitive Nanoparticles from Cells Prevents Them from Remaining in Cells after Photoporation

Advanced Science, EarlyView.
Phenylboronic acid‐functionalized gold nanoparticles reversibly attach to cell‐surface glycans, enhancing photoporation‐mediated intracellular delivery. After irradiation, ATP competitively disrupts the boronic ester interactions and removes cell‐associated nanoparticles, markedly reducing residual gold.
Tao Lu, Mina Nikolić, Baihao Huang, Deep Punj, Herlinde De Keersmaecker, Thibaut Van Acker, Wenjia Xie, Florian Vanlauwe, Phillip Blondeel, Liesl De Graeve, Félix Sauvage, Ranhua Xiong, Chaobo Huang, Frank Vanhaecke, Kevin Braeckmans, Stefaan C. De Smedt   +15 more
wiley   +1 more source

Hierarchical Nanoplatform Integrating Oxidative–Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy

Advanced Science, EarlyView.
A hierarchical CM/LDH nanoplatform integrates ROS‐scavenging Ce‐MOF nanozymes with acid‐neutralizing CaAl‐LDH and is delivered within GelMA hydrogel to diabetic bone defects. By remodeling the oxidative‐acidic microenvironment, preserving mitochondrial homeostasis, and suppressing mtDNA–cGAS–STING inflammatory signaling, CM/LDH reduces proinflammatory ...
Xu Chen, Xingyu Zhu, Zhixin Qiu, Yijia Zhu, Xinhui Zheng, Dongqi Fan, Jinglei Zhan, Congxiu Mao, Ping Ji, Tao Chen, Qingqing He   +10 more
wiley   +1 more source

Multimodal optical coherence tomography and two-photon light sheet fluorescence microscopy for embryo imaging. [PDF]

J Biomed Opt
Karim MM, Sun R, Khajavi B, Singh M, Ambekar YS, Schill AW, Aglyamov SR, Mayerich D, Larin KV.   +8 more
europepmc   +1 more source

Digital Brain Maps and Virtual Neuroscience: An Emerging Role for Light-Sheet Fluorescence Microscopy in Drug Development. [PDF]

Front Neurosci, 2022
Perens J, Hecksher-Sørensen J.
europepmc   +1 more source

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source

Illuminating Satellite Cells: Light Sheet Fluorescence Microscopy for 3D Imaging of Murine Skeletal Muscles Damaged by Ex Vivo Forced Eccentric Contraction. [PDF]

Microsc Res Tech
Garella R, Imbimbo E, Palmieri F, Tani A, Parigi M, Chellini F, La Contana A, Belmonte MM, Longhin A, Silvestri L, Sassoli C, Squecco R.   +11 more
europepmc   +1 more source

Light sheet fluorescence microscopy for the investigation of blood-sucking arthropods dyed via artificial membrane feeding. [PDF]

Parasit Vectors, 2022
Ten Bosch L, Habedank B, Candeo A, Bassi A, Valentini G, Gerhard C.   +5 more
europepmc   +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

Advanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park, Yunha Hwang, Jimin Kwak, Yuxi Lin, Hye‐Yeon Park, Eunju Nam, Jiyeon Han, Soyeon Park, Hyunyong Kim, Ju‐Eun Kim, Hyun Goo Kang, Jiyong Park, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Seung Jae Lee, Mi Hee Lim   +16 more
wiley   +1 more source

First application of three-dimensional light sheet fluorescence microscopy to human testicular tumors: New perspectives in histopathology. [PDF]

Andrology
Pinkert-Leetsch D, Kareem A, Merz SF, Teckentrup M, Fichtner A, Bremmer F, Missbach-Guentner J.   +6 more
europepmc   +1 more source

Erratum: Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publisher's note. [PDF]

Biomed Opt Express, 2022
Li C, Moatti A, Zhang X, Ghashghaei HT, Greenbaum A.   +4 more
europepmc   +1 more source