Results 101 to 110 of about 17,219,574 (393)

Regulatory Horcruxes [PDF]

open access: yes, 2018
The regulator that designs and first implements a federal regulatory program does not always have the ability to control the timing and process of how that regulatory program will, in this Symposium’s language, “exit.” As the 2016 election has ...
Light, Sarah E.
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Rejection versus forceful imposition during elections: the ‘I have come to stay’ mindset of the incumbent

open access: yesHumanities & Social Sciences Communications
Political actors may resort to drastic measures, including election-related violence, to pursue electoral victory. While free and fair elections are fundamental to any democratic system, electoral violence threatens the integrity of this process and ...
Light Iwhuechiokike Nyeche
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

The Social Context of Racial Boundary Negotiations: Segregation, Hate Crime, and Hispanic Racial Identification in Metropolitan America

open access: yesSociological Science, 2016
How the influx of Hispanics is reshaping the U.S. racial landscape is a paramount question in sociology. While previous research has noted the significant differences in Hispanics’ racial identifications from place to place, there are comparatively few ...
Michael T. Light, John Iceland
doaj   +1 more source

Light Light by Julie Joosten [PDF]

open access: yes, 2015
Mathieu Aubin\u27s review of Light Light by Julie ...
Aubin, Mathieu
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

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