Results 31 to 40 of about 4,545,693 (268)

Rapid pathogen identification and phenotypic antimicrobial susceptibility directly from urine specimens

Scientific Reports, 2022
Implementing effective antimicrobial therapy close to the onset of infection lowers morbidity and mortality and attenuates the spread of antimicrobial resistance.
Larry Burg, Gretel Crewe, James DiMeo, Xin Guo, Carmen G. Li, Melissa Mayol, Andrew Tempesta, William Lauzier, Rachelle Markham, Katarzyna Crissy, Colleen Barry, Bruce Walsh, James E. Kirby, Don Straus   +13 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays [PDF]

, 2021
Essyrose Mathew, Giulia Pitzanti, Ana L. Gomes dos Santos, Dimitrios A. Lamprou   +3 more
openalex   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Kappa Free Light Chain Biomarkers Are Efficient for the Diagnosis of Multiple Sclerosis [PDF]

, 2022
Michaël Levraut, Sabine Laurent‐Chabalier, Xavier Ayrignac, Kévin Bigaut, Manon Rival, Sanae Squalli, Hélène Zéphir, Tifanie Alberto, Jean David Pekar, Jonathan Ciron, Damien Biotti, Bénédicte Puissant‐Lubrano, Jean‐Philippe Camdessanché, Yannick Tholance, Olivier Casez, Bertrand Toussaint, Jeanne Marion, Thibault Moreau, Daniela Lakomy, Audrey Thomasset, Élisabeth Maillart, Delphine Sterlin, Aude Maurousset, Auriane Rocher, David Laplaud, Edith Bigot‐Corbel, Pierre‐Olivier Bertho, Jean Pelletier, José Boucraut, Pierre Labauge, Thierry Vincent, J. de Sèze, Isabelle Jahn, Barbara Seitz‐Polski, Éric Thouvenot, Christine Lebrun‐Frénay   +35 more
openalex   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Constructivisme et pédagogie dans l’enseignement de la natation

eJournal de la Recherche sur l'Intervention en Éducation Physique et Sport, 2012
Cette contribution souhaite faire le point sur la possible contribution du constructivisme au renouvellement d’une pédagogie de la natation. Si les pédagogies orientées par le constructivisme ont profondément renouvelé les manières d’appréhender l ...
Richard Light, Yannick Lémonie
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Cultivating sustainable developments with makerspaces | Cultivando desenvolvimento sustentável com espaços maker

Liinc em Revista, 2017
RESUMO Em outubro de 2915, organizamos uma oficina para 80 pesquisadores e praticantes envolvidos em makerspaces na Europa. Nosso objetivo era explorar como os makerspaces podem fomentar desenvolvimento sustentável.
Adrian Smith, Ann Light
doaj   +1 more source