Results 81 to 90 of about 13,240,817 (334)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

On social function: new language for discussing technology for social action [PDF]

open access: yes, 2008
Designers of technology for social action can often become embroiled in issues of platform and technical functionality at a very early stage in the development process, before the precise social value of an approach has been explored.
Dearden, Andy, Light, Ann
core  

HIGHLIGHTING CHANGES IN TWO RUSSIAN SCHOOLS WITH SUCCESSFUL ONE-TO-ONE LAPTOP PROGRAMS: MOSCOW AND NIZHNY NOVGOROD CASE STUDIES

open access: yesОткрытое образование (Москва), 2016
One-to-one educational model of mobile learning at school is essential part of Innovative education reform and modernization of Russian educational system [1].
Daniel Light, Elizabeth Pierson
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Using HEC-FIA to identify Indirect Economic Losses

open access: yesE3S Web of Conferences, 2016
The United States Army Corps of Engineers’ Hydrologic Engineering Center developed the HEC-FIA (Flood Impact Analysis) software to assist in the estimation of consequences with uncertainty.
Lehman William, Light Miles
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Reconfiguring Socialist Urban Landscapes: The ‘Left-Over’ Spaces of State-Socialism in Bucharest [PDF]

open access: yesHuman Geographies: Journal of Studies and Research in Human Geography, 2010
The end of state-socialism has produced complex processes of urban change in East and Central Europe including the reshaping of urban identities and urban cultural landscapes in post-socialist cities.
Duncan Light , Craig Young
doaj  

Evidence for a heritable predisposition to Chronic Fatigue Syndrome

open access: yesBMC Neurology, 2011
Background Chronic Fatigue Syndrome (CFS) came to attention in the 1980s, but initial investigations did not find organic causes. Now decades later, the etiology of CFS has yet to be understood, and the role of genetic predisposition in CFS remains ...
Bateman Lucinda   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy