Results 111 to 120 of about 1,009,600 (313)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Axonemal dynein light chain-1 locates at the microtubule-binding domain of the γ heavy chain

, 2015
Muneyoshi Ichikawa, Kei Saito, Haruaki Yanagisawa, Toshiki Yagi, Ritsu Kamiya, Shin Yamaguchi, Junichiro Yajima, Yasuharu Kushida, Kentaro Nakano, Osamu Numata, Yoko Y. Toyoshima   +10 more
openalex   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Central nervous system multiple myeloma – potential roles for intrathecal therapy and measurement of cerebrospinal fluid light chains [PDF]

, 2013
Denise Lee, Anna Kalff, Michael Löw, Shane Gangatharan, Prahlad Ho, Ashish Bajel, David Ritchie, Andrew Grigg, Andrew Spencer   +8 more
openalex   +1 more source

Immunoglobulin Light Chains Control Permissiveness to Malignant B-Cell Transformation By RAS-Pathway Lesions [PDF]

, 2023
Lai N. Chan, Kohei Kume, Christian Hurtz, Mark E. Robinson, Kadriye Nehir Cosgun, Markus Müschen   +5 more
openalex   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

ATP Augments von Willebrand Factor-dependent Shear-induced Platelet Aggregation through Ca2+-Calmodulin and Myosin Light Chain Kinase Activation [PDF]

, 2004
Cécile Oury, Elsie Sticker, Heidi Cornelissen, Rita De Vos, Jos Vermylen, Marc Hoylaerts   +5 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

The Interdomain Disulfide Bond of a Homogeneous Rabbit Pneumococcal Antibody Light Chain [PDF]

, 1975
A. Donny Strosberg, Michael N. Margolies, Edgar Haber   +2 more
openalex   +1 more source

99mTc-DPD scintigraphy in immunoglobulin light chain (AL) cardiac amyloidosis [PDF]

, 2021
Candida Cristina Quarta, Jiexin Zheng, David F. Hutt, Simona F Grigore, Richa Manwani, Sajitha Sachchithanantham, Shameem Mahmood, Carol Whelan, Marianna Fontana, Ana Martinez–Naharro, Liza Chacko, Helen J. Lachmann, Julian D. Gillmore, Claudio Rapezzi, Philip N. Hawkins, Ashutosh Wechalekar   +15 more
openalex   +1 more source