Results 121 to 130 of about 1,009,600 (313)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Differences in Immunoglobulin Light Chain Species Found in Urinary Exosomes in Light Chain Amyloidosis (AL)

, 2012
Marina Ramı́rez-Alvarado, Christopher J. Ward, Bing Huang, Xun Gong, Marie C. Hogan, Benjamin J. Madden, M. Cristine Charlesworth, Nelson Leung   +7 more
openalex   +2 more sources

N-glycosylation of monoclonal light chains on routine MASS-FIX testing is a risk factor for MGUS progression

, 2020
Angela Dispenzieri, Dirk R. Larson, S. Vincent Rajkumar, Robert A. Kyle, Shaji Kumar, Taxiarchis Kourelis, Bonnie K. Arendt, Maria Willrcih, Surendra Dasari, David Murray   +9 more
openalex   +2 more sources

Free Immunoglobulin Light Chains in Patients with Tick-Borne Encephalitis: Before and after Treatment [PDF]

, 2021
Monika Gudowska-Sawczuk, Piotr Czupryna, Anna Moniuszko‐Malinowska, Sławomir Pancewicz, Barbara Mroczko   +4 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Light chain plasmacytoid lymphocytic lymphoma [PDF]

, 1981
Antonio Tabilio, Cristina Mecucci, Brunangelo Falini, Maria Paola Martelli   +3 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

A Novel Transforming Growth Factor-β Receptor-interacting Protein That Is Also a Light Chain of the Motor Protein Dynein

, 2002
Qian Tang, Cory M. Staub, Guofeng Gao, Qunyan Jin, Zhengke Wang, Wei Ding, Rosemarie Aurigemma, Kathleen M. Mulder   +7 more
openalex   +1 more source

Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis [PDF]

, 2017
Jean‐Baptiste Gibier, Viviane Gnemmi, François Glowacki, Eileen M. Boyle, Benjamín López, Evelyne MacNamara, Maxime Hoffmann, Raymond Azar, Thomas Guincestre, Franck Bourdon, Marie-Christine Copin, David Buob   +11 more
openalex   +1 more source