Results 151 to 160 of about 8,570,567 (357)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications
Molecular Oncology, EarlyView.Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker +3 more
wiley +1 more source
Ultrasonics SonochemistryThis research investigated the impacts of various ultrasonic power (0, 150 W, 300 W, 450 W, 600 W) treatments on chickpea protein isolate (CPI) and their ability to stabilize Pickering emulsions.
Bingbing Cui +7 more
doaj +1 more source
Shocks in non-loaded bead chains with impurities
, 1999 We numerically investigate the problem of the propagation of a shock in an horizontal non-loaded granular chain with a bead interaction force exponent varying from unity to large values.
Hascoet, E., Herrmann, H.
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Visual Analysis of Research Progress on Protein Deamidation Based on CiteSpace Knowledge Map
Liang you shipin ke-jiIn order to explore the research hotspots and development trends of protein deamidation, this paper systematically searched 133 Chinese literatures and 337 English literatures on protein deamidation in the CNKI and WOS databases, and the CiteSpace ...
LIU Xing-li +5 more
doaj +1 more source
The information value chain: emerging models for procuring electronic publications [PDF]
, 2000 The first part of this paper examines the information supply chain and some of its concepts; particular attention is paid to features differentiating electronic from printed information. The second part discusses the procurement process and, in the light
Ball, David, Wright, Susan
core
Dynamical approach to chains of scatterers
, 2007 Linear chains of quantum scatterers are studied in the process of lengthening, which is treated and analysed as a discrete dynamical system defined over the manifold of scattering matrices.
Abrahams E +15 more
core +1 more source