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The American Journal of Medicine, 1981
In 13 specimens of renal tissue from 11 patients, deposits of monoclonal immunoglobulin light chains and continuous granular electron-dense material within tubular basement membranes and in association with the glomerular basement membrane were identified.
R R, Tubbs +5 more
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In 13 specimens of renal tissue from 11 patients, deposits of monoclonal immunoglobulin light chains and continuous granular electron-dense material within tubular basement membranes and in association with the glomerular basement membrane were identified.
R R, Tubbs +5 more
openaire +3 more sources
Blood, 2013
![Figure][1] A 67-year-old man with an elevated creatinine (231 mmol/L) was found to have an elevated IgG monoclonal gammopathy. A renal biopsy identified light chain deposition. Routine staining by hematoxylin and eosin stain revealed acute tubular necrosis, with tubular dilatation,
Cyrus C, Hsia, Nancy G, Chan
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![Figure][1] A 67-year-old man with an elevated creatinine (231 mmol/L) was found to have an elevated IgG monoclonal gammopathy. A renal biopsy identified light chain deposition. Routine staining by hematoxylin and eosin stain revealed acute tubular necrosis, with tubular dilatation,
Cyrus C, Hsia, Nancy G, Chan
openaire +2 more sources
Light-chain cardiac amyloidosis
Current Problems in Cancer, 2017Cardiac amyloidosis is an underrecognized condition, in which delays to diagnosis have great implications on management options, prognosis, and morbidity. Once cardiac tissue is infiltrated by amyloid fibrils, there is a cascade of pathologic changes that can display an array of clinical manifestations, from impaired relaxation of the ventricular ...
Anit K, Mankad +2 more
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Journal of Muscle Research & Cell Motility, 1997
Calcium ions (Ca2+) has been recognized as an important component in muscle contraction and cell motility because it regulates a distinct class of protein kinases, myosin light chain kinases. Striated muscles, including cardiac and skeletal muscle tissues, have served as useful models for studying the mechanism by which Ca2+ regulates contractile ...
P J, Gallagher, B P, Herring, J T, Stull
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Calcium ions (Ca2+) has been recognized as an important component in muscle contraction and cell motility because it regulates a distinct class of protein kinases, myosin light chain kinases. Striated muscles, including cardiac and skeletal muscle tissues, have served as useful models for studying the mechanism by which Ca2+ regulates contractile ...
P J, Gallagher, B P, Herring, J T, Stull
openaire +2 more sources
New England Journal of Medicine, 1976
We observed idiopathic light-chain proteinuria in a patient with multiple abnormalities of proximal-tubule transport mechanisms (Fanconi syndrome), nephrogenic diabetes insipidus, and distal renal tubular acidosis. Seventeen of the 19 urinary amino acid levels measured were elevated.
N, Smithline, J P, Kassirer, J J, Cohen
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We observed idiopathic light-chain proteinuria in a patient with multiple abnormalities of proximal-tubule transport mechanisms (Fanconi syndrome), nephrogenic diabetes insipidus, and distal renal tubular acidosis. Seventeen of the 19 urinary amino acid levels measured were elevated.
N, Smithline, J P, Kassirer, J J, Cohen
openaire +3 more sources
Immunoglobulin light chain amyloidosis
Expert Review of Hematology, 2013Primary light chain amyloidosis is the most common form of systemic amyloidosis and is caused by misfolded light chains that cause proteotoxicity and rapid decline of vital organ function. Early diagnosis is essential in order to deliver effective therapy and prevent irreversible organ damage.
MERLINI, GIAMPAOLO +4 more
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