Results 31 to 40 of about 1,009,600 (313)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The role of notch signaling pathway and non-coding RNAs in cancer and inflammation: progress, therapeutic insights, and future directions

Frontiers in Immunology
The Notch signaling pathway and non-coding RNAs (ncRNAs) play significant roles in regulating key cellular processes such as cancer progression, metastasis, and drug resistance.
Rong-Zu Nie, Rong-Zu Nie, Hang Wang, Hang Wang, Shuang-Shuang Wang, Shuang-Shuang Wang, Chen Chen, Chen Chen, Huo-Min Luo, Huo-Min Luo, Hao-Kun Zhang, Hao-Kun Zhang, Zhao-Hui Jing, Zhao-Hui Jing, Pei-Feng Li, Pei-Feng Li   +15 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Research on non-destructive detection of chilled meat quality based on hyperspectral technology combined with different data processing methods

Frontiers in Nutrition
This study utilized hyperspectral technology in conjunction with chemometric methods for the non-destructive assessment of chilled meat quality. Average spectra were extracted from regions of interest within hyperspectral images and further optimized ...
Zeyu Xu, Zeyu Xu, Zeyu Xu, Yu Han, Yu Han, Yu Han, Shuai Chen, Shuai Chen, Shuai Chen, Dianbo Zhao, Dianbo Zhao, Dianbo Zhao, Huanli Yao, Huanli Yao, Huanli Yao, Jiale Hao, Junguang Li, Junguang Li, Junguang Li, Ke Li, Ke Li, Ke Li, Shengjie Li, Yanhong Bai, Yanhong Bai, Yanhong Bai   +25 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Plant-based dietary miRNAS: cross-border regulatory factors for regulating glycolipid metabolism and their nutritional intervention strategies

Frontiers in Nutrition
Disorders of glucose and lipid metabolism represent a major global health burden, driving the need for innovative nutritional interventions. Emerging evidence suggests that dietary microRNAs (miRNAs) from plants can act as cross-kingdom regulators. These
Yaping Liu, Yaping Liu, Yaping Liu, Yaping Liu, Xingyue Tao, Xingyue Tao, Xingyue Tao, Xingyue Tao, Xiaoxiao Wang, Xiaoxiao Wang, Xiaoxiao Wang, Xiaoxiao Wang, Huilin Lv, Huilin Lv, Huilin Lv, Huilin Lv, Huomin Luo, Huomin Luo, Huomin Luo, Huomin Luo, Peifeng Li, Peifeng Li, Peifeng Li, Peifeng Li   +23 more
doaj   +1 more source

Paraffin Immunofluorescence Increases Light-Chain Detection in Extra-Renal Light Chain Amyloidosis and Other Light-Chain–Associated Diseases [PDF]

Archives of Pathology & Laboratory Medicine, 2020
Context.— Distinguishing the different types of amyloid is clinically important because treatments and outcomes are different. Mass spectrometry is the new gold standard for amyloid typing, but it is costly and not widely available.
Jean-Baptiste, Gibier, Romain, Perbet, Benjamin, Lopez, Magali, Colombat, Romain, Dubois, Sarah, Humez, Louis, Terriou, Marie-Christine, Copin, Viviane, Gnemmi   +8 more
openaire   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Tumor-dependent myeloid and lymphoid cell recruitment in genO-BRGSF-HIS mice: a novel tool for evaluating immunotherapies

Frontiers in Immunology
ObjectivesPreclinical models that accurately recapitulate the human immune response, particularly within the tumor microenvironment (TME), are needed for the translational and predictive testing of new therapies.
Gaëlle H. Martin, Siham Hedir, Florent Creusat, Alexis Gonon, Amélie Marguier, Perrine Martin-Jeantet, Lise Nouveau, Laura Cons, Florence Renart-Depontieu, Valery Moine, Marc Derive, Yacine Cherifi, Margarida T. Grilo Ruivo, Fabiane Sônego, Kader Thiam   +14 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source