Results 31 to 40 of about 2,711,435 (306)

Targeting CEACAM5-positive solid tumors using NILK-2401, a novel CEACAM5xCD47 κλ bispecific antibody

Frontiers in Immunology
BackgroundBlocking the CD47 “don’t eat me”-signal on tumor cells with monoclonal antibodies or fusion proteins has shown limited clinical activity in hematologic malignancies and solid tumors thus far.
Anja Seckinger, Anja Seckinger, Vanessa Buatois, Valéry Moine, Bruno Daubeuf, Françoise Richard, Laurence Chatel, Alizée Viandier, Nicolas Bosson, Emeline Rousset, Krzysztof Masternak, Susana Salgado-Pires, Claudia Batista, Christelle Mougin, Flora Juan-Bégeot, Yves Poitevin, Dirk Hose, Dirk Hose   +17 more
doaj   +1 more source

Collective Light Emission of a Finite Size Atomic Chain

, 2012
Radiative properties of collective electronic states in a one dimensional atomic chain are investigated. Radiative corrections are included with emphasize put on the effect of the chain size through the dependence on both the number of atoms and the ...
Agranovich V. M., Bouwmeester D., Craig D. P., Davydov S., Hashem Zoubi, Loudon R., Mewton C. J., Zoubi H., Zoubi H., Zoubi H., Zoubi H., Zoubi H., Zoubi H. Ritsch H.   +12 more
core   +1 more source

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies

Journal for ImmunoTherapy of Cancer
Background Owing to their roles in promoting T cell and natural killer (NK) cell activation and proliferation, interleukins-2 (IL-2) and interleukins-15 (IL-15) have been pursued as promising pathways to target in cancer immunotherapy. Nonetheless, their
Camilla Jandus, Walter Ferlin, Sébastien Calloud, Alizée Viandier, Pauline Malinge, Nicolas Fischer, Limin Shang, Krzysztof Masternak, Julien Montorfani, Eric Hatterer, Laurence Chatel, Adeline Lesnier, Bruno Daubeuf, Lise Nouveau   +13 more
doaj   +1 more source

Bacillus vallismortis TU-Orga21 blocks rice blast through both direct effect and stimulation of plant defense

Frontiers in Plant Science, 2023
Beneficial microorganisms are an important strategy for sustainable plant production processes such as stimulate root exudation, stress tolerance, and yield improvement.
Wannaporn Thepbandit, Anake Srisuwan, Supatcharee Siriwong, Siriwan Nawong, Dusit Athinuwat, Dusit Athinuwat   +5 more
doaj   +1 more source

Light-chain nephropathy

Kidney International, 1985
Case presentation A 65-year-old woman, first evaluated at New England Medical Center approximately 4 years ago for hypertension, was found to have glycosuria with a concomitant serum glucose level of 95 mg/dl. Serum uric acid was 2.1 mg/dl, the serum phosphorus was 1.8 mg/dl, and the patient had a hyperchioremic metabolic acidosis; the serum ...
openaire   +2 more sources

Reversible Jump Metropolis Light Transport using Inverse Mappings

, 2017
We study Markov Chain Monte Carlo (MCMC) methods operating in primary sample space and their interactions with multiple sampling techniques. We observe that incorporating the sampling technique into the state of the Markov Chain, as done in Multiplexed ...
Bitterli, Benedikt, Jakob, Wenzel, Jarosz, Wojciech, Novák, Jan   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Notch signaling pathway modulation by food functional ingredients: mechanisms, cancer and immunoregulation

Frontiers in Cell and Developmental Biology
This article comprehensively reviews the complex role of the Notch signaling cascade in cancer, as well as the regulatory mechanisms and potential anti-cancer effects of food functional ingredients on this pathway.
Rong-Zu Nie, Rong-Zu Nie, Rong-Zu Nie, Huo-Min Luo, Huo-Min Luo, Huo-Min Luo, Ya-Ping Liu, Ya-Ping Liu, Ya-Ping Liu, Shuang-Shuang Wang, Shuang-Shuang Wang, Shuang-Shuang Wang, Yan-Jie Hou, Yan-Jie Hou, Yan-Jie Hou, Chen Chen, Chen Chen, Chen Chen, Hang Wang, Hang Wang, Hang Wang, Hui-Lin Lv, Hui-Lin Lv, Hui-Lin Lv, Xing-Yue Tao, Xing-Yue Tao, Xing-Yue Tao, Zhao-Hui Jing, Zhao-Hui Jing, Zhao-Hui Jing, Hao-Kun Zhang, Hao-Kun Zhang, Hao-Kun Zhang, Pei-Feng Li, Pei-Feng Li, Pei-Feng Li   +35 more
doaj   +1 more source

Driven Dynamics: A Probable Photodriven Frenkel-Kontorova Model

, 2002
In this study, we examine the dynamics of a one-dimensional Frenkel-Kontorova chain consisting of nanosize clusters (the ''particles'') and photochromic molecules (the ''bonds''), and being subjected to a periodic substrate potential.
B. N. J. Persson, Bambi Hu, F. Marchesoni, H. S. J. van der Zant, Jian-Yang Zhu, L. M. Floria, M. Irie, M. Porto, M. V. Paliy, M. Weiss, O. M. Braun, P. Hänggi, P. J. Martinez, R. A. Guyer, S. Watanabe, T. Strunz, T. Tsujioka, Ya. Frenkel   +17 more
core   +1 more source