Results 181 to 190 of about 118,795 (255)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Lunar synchronization of hemostasis and immunity validates prophetic timing of hijama therapy: A multicenter study from Yemen. [PDF]

J Taibah Univ Med Sci
Ali NT, Abdullah RS, Ahmed I, Mohammed O, Jamal A, Ahmed F, Dahan B, Adel A, Abdullah T, Saleh M, Hamid S, Mohammed N, Mohammed K, Khalid Y, Nabil S, Abdualkareem A.   +15 more
europepmc   +1 more source

Droplet microfluidics: Enabling the tailored fabrication of hydrogel particles

Droplet, EarlyView.
Droplet microfluidics enables precise, versatile fabrication of hydrogel particles with controlled size, composition, and structure. This review summarizes fundamental principles, engineering strategies, and emerging applications, providing a framework for advancing microfluidic hydrogel technologies.
Zhongqiao Gan, Xu Hou
wiley   +1 more source

Pathogenic interplay between markedly elevated plasma lipoprotein(a) levels and prothrombotic mechanisms: a case report. [PDF]

Front Cardiovasc Med
Biolo M, Napolitano A, Spiezia L, Bulato C, Toffanin S, Regazzo D, Portinari C, Zambon A, Simioni P.   +8 more
europepmc   +1 more source

All‐in‐One Intelligent Hemostatic Sponge: Rapid Hemostasis for Non‐Compressive Wounds With Synergetic Enhanced Antibacterial Efficacy and Self‐Reporting Biodegradation

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Clinicians often concurrently tackle critical challenges including emergency hemorrhage, secondary infection, and the elusive tracking of biodegradation of conventional hemostatic agents for complex wounds. Here, we report an intelligent hemostatic sponge (spCS@AIE) by incorporating aggregation‐induced emission (AIE) nanoparticles with short‐wave ...
Zhicheng Liu, Yan Zhang, Mengmeng Wang, Ye Li, Heng Sun, Lanqiong Zhang, Xin Bai, Haicheng Wei, Zhi Wang, Hao Guan, Yanzi Xu, Dongfeng Dang, Lingjie Meng   +12 more
wiley   +1 more source

Phase-specific dynamics of coagulation factors V, VIII, and XIII during liver transplantation: insights from a prospective study. [PDF]

Perioper Med (Lond)
Thaler S, Zorn A, Aster I, Koliogiannis D, Guba M, Renz BW, Groene P.   +6 more
europepmc   +1 more source

Acquired platelet dysfunction induced by infection in an older patient: Severe hemorrhage despite normal platelet count. [PDF]

SAGE Open Med Case Rep
Jiang Y, Lu N, Chang X, Guo Y, Liu J, Ru Y, Wu W.   +6 more
europepmc   +1 more source

Repurposing piroxicam for antithrombotic and cardiopulmonary protection: Pharmacological rationale and therapeutic potential.

Indian J Pharmacol
Khalid W, Khan AU.
europepmc   +1 more source

Biphasic modulation of large-fiber excitability accompanied by dynamic nerve-intrinsic immune activation following CFA-induced peripheral inflammation in mice. [PDF]

Sci Rep
Berkowitz S, Golderman V, Goldberg Z, Yerushkin A, Goldberg O, Chapman J, Dori A, Maggio N, Ziv T, Devaux JJ, Shavit-Stein E.   +10 more
europepmc   +1 more source