Results 211 to 220 of about 121,732 (299)

ANK1 and EPB41 Variants and the Risk of Steroid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Bronchoscopy guided resection of endobronchial mucormycosis in a renal transplant patient with chronic graft rejection: A non-surgical approach using bronchoscopy guided intervention as salvage therapy. [PDF]

Respir Med Case Rep
Afrin S, Mohammed FR, Haq M.
europepmc   +1 more source

Arthroscopic Repair of Radial Meniscal Tear Using Fibrin Clot Augmentation and “Hashtag” Style Inside‐Out Technique

Arthroscopy Techniques, EarlyView.
Abstract Significant meniscal injuries lead to pain and possible early osteoarthritis development. Fibrin clot augmentation represents an effective, cost‐efficient method for improving healing rates in poorly vascularized meniscal tears. This arthroscopic technique shows fibrin clot augmentation combined with horizontal and vertical mattress sutures in
Siddharth Padmanabhan, Helena Franco, Peter Myers, Francois Tudor   +3 more
wiley   +1 more source

A three-dimensional shear dependent continuum model of platelet aggregation under flow. [PDF]

PLoS Comput Biol
Montgomery D, Barrientos ES, Grdadolnik JM, Hendrickson K, Fogelson AL, Neeves KB, Leiderman K.   +6 more
europepmc   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Identifying therapeutic target genes for stroke through systematic druggable Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Xia J, Zheng J, Zou S, Zhao H, Liu Q, Zhang R, Xu L.   +6 more
europepmc   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Clinical characteristics and prognosis of immunoglobulin light chain amyloidosis patients. [PDF]

Front Med (Lausanne)
Song L, Su Y, Li R, Du S, Xue Y, Gu Y, Chen J, Xing X, Shen Z, Wei Y.   +9 more
europepmc   +1 more source

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source

Daily biomarker trajectories predict major bleeding in patients on venovenous ECMO for ARDS: a retrospective longitudinal cohort study. [PDF]

Sci Rep
Stueber T, Homeier JM, Gillmann HJ, Wassong J, Jung C.   +4 more
europepmc   +1 more source