Results 131 to 140 of about 665,153 (306)

The Scaling Law in Stellar Light Curves

CoRR
Analyzing time series of fluxes from stars, known as stellar light curves, can reveal valuable information about stellar properties. However, most current methods rely on extracting summary statistics, and studies using deep learning have been limited to supervised approaches. In this research, we investigate the scaling law properties that emerge when
Jiashu Pan, Yuan-Sen Ting, Yang Huang, Jie Yu, Ji-Feng Liu   +4 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Conformal holography with curved light sheets

Optics Express
Projecting images onto arbitrary curved surfaces is a sought-after goal in computer-generated holography applications. However, achieving high axial resolution with a low level of cross-talk using a single computer-generated hologram is still challenging. Here we propose and demonstrate a new type of holographic technique that projects conformal images
Vinicius S. Angelis, Ahmed H. Dorrah, Leonardo A. Ambrosio, Federico Capasso   +3 more
openaire   +2 more sources

Theoretical light and velocity curves for Cepheid variables. [Nonlinear models]

, 1978
New Research Initiatives Program W-318 was successfully completed with the calculation of a series of nonlinear Cepheid models with the new DYN code. The dynamical zoning feature of the DYN code makes it unique in that it allows reliable light curves, as
Adams, T. F., Davis, C. G., Keller, C. F.   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Unsupervised classification of eclipsing binary light curves through k-medoids clustering. [PDF]

J Appl Stat, 2020
Modak S, Chattopadhyay T, Chattopadhyay AK.   +2 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Searching In Light Curves

, 2017
This research was supported by grant COST LD-15113 of the Ministry of Education Youth and Sports of the Czech Republic.
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source