Results 61 to 70 of about 598,532 (267)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Hydrogen-poor Superluminous Supernovae with Bumpy Light Curves Powered by Precessing Magnetars

The Astrophysical Journal
Recent observations and statistical studies have revealed that a significant fraction of hydrogen-poor superluminous supernovae (SLSNe-I) exhibit light curves that deviate from the smooth evolution predicted by the magnetar-powered model, instead showing
Biao Zhang, Long Li, Zi-Gao Dai, Shu-Qing Zhong   +3 more
doaj   +1 more source

Light curves and colours of the ejecta from Dimorphos after the DART impact. [PDF]

Nature, 2023
Graykowski A, Lambert RA, Marchis F, Cazeneuve D, Dalba PA, Esposito TM, O'Conner Peluso D, Sgro LA, Blaclard G, Borot A, Malvache A, Marfisi L, Powell TM, Huet P, Limagne M, Payet B, Clarke C, Murabana S, Owen DC, Wasilwa R, Fukui K, Goto T, Guillet B, Huth P, Ishiyama S, Kukita R, Mitchell M, Primm M, Randolph J, Rivett DA, Ryno M, Shimizu M, Toullec JP, Will S, Yue WC, Camilleri M, Graykowski K, Janetzke R, Janke D, Kardel S, Loose M, Pickering JW, Smith BA, Transom IM.   +43 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

BLADE: An Automated Framework for Classifying Light Curves from the Center for Near-Earth Object Studies Fireball Database

The Astronomical Journal
Fireballs (bolides) are high-energy luminous phenomena produced when meteoroids and small asteroids enter Earth’s atmosphere at hypersonic speeds, often resulting in fragmentation or complete disintegration accompanied by significant energy release.
Elizabeth A. Silber, Vedant Sawal
doaj   +1 more source

Photoelectric Observations and Analysis of the Contact Binary W UMa [PDF]

Journal of Astronomy and Space Sciences, 2001
The unpublished photoelectric observations of the contact binary W UMa in ultraviolet, blue, and yellow bandpasses made on four nights during the observing seasons from April, 1984 to May, 1985 were presented.
Chun-Hwey Kim, Chung Uk Lee, Young Woon Kang   +2 more
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Physics-driven Explosions of Stripped High-mass Stars: Synthetic Light Curves and Spectra of Stripped-envelope Supernovae with Broad Light Curves

The Astrophysical Journal
Stripped-envelope supernovae (SESNe) represent a significant fraction of core-collapse supernovae, arising from massive stars that have shed their hydrogen and, in some cases, helium envelopes. The origins and explosion mechanisms of SESNe remain a topic
Jing Lu, Brandon L. Barker, Jared Goldberg, Wolfgang E. Kerzendorf, Maryam Modjaz, Sean M. Couch, Joshua V. Shields, Andrew G. Fullard   +7 more
doaj   +1 more source