Results 91 to 100 of about 4,135,676 (258)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Change detection in multisensor SAR images using bivariate gamma distributions [PDF]

, 2008
This paper studies a family of distributions constructed from multivariate gamma distributions to model the statistical properties of multisensor synthetic aperture radar (SAR) images.
Chatelain, Florent, Tourneret, Jean-Yves, Inglada, Jordi   +2 more
core   +1 more source

Gluon GTMDs at nonzero skewness and impact parameter dependent parton distributions

European Physical Journal C: Particles and Fields
We investigate the leading twist generalized transverse momentum dependent parton distributions (GTMDs) of the unpolarized and longitudinally polarized gluons in the nucleon.
Chentao Tan, Zhun Lu
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Precise Optical Modeling of Phosphor-Converted LEDs With Arbitrary Concentration and Thickness Using Bidirectional Scattering Distribution Function

IEEE Photonics Journal, 2018
Phosphor-converted light-emitting diode (pcLED) is one of the most promising methods to generate white light. The interaction of the excitation light with the phosphor in pcLED is a complicated phenomenon, combining light absorption, light conversion ...
Jia-Sheng Li, Yong Tang, Zong-Tao Li, Jia-Xiao Chen, Xin-Rui Ding, Bin-Hai Yu   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Poincaré Covariant Light-Front Spectral Function and Transverse Momentum Distributions

, 2020
In valence approximation the fermion correlator is simply related to the light-front spectral function. Then the leading twist time-reversal even transverse momentum distributions can be explicitly obtained from the light-front wave function of the ...
Salme G., Pace E., Scopetta S.
core   +1 more source

The Statistical Study of the Daily Fermi Light Curves of 130 Sources

Galaxies, 2017
Blazars show rapid and high amplitude variability. It is interesting to question what kind of process the variability corresponds to. Maybe it is a result of the instability of the accretion flows.
Wei Cai, Yi Liu, Jun H. Fan
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Energy distribution of a stationary beam of light [PDF]

Astrophysics and Space Science, 2005
Latex, no figures [Admin note: substantial overlap with gr-qc/9910015 and hep-th/0308070]
openaire   +2 more sources