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Skewed generalized parton distributions of proton from basis light-front quantization

Physics Letters B
We obtain all the leading-twist quark generalized parton distributions (GPDs) inside the proton at nonzero skewness within the basis light-front quantization framework.
Yiping Liu +5 more
doaj +1 more source

Extreme value distributions for dependent jointly ln,p-symmetrically distributed random variables

Dependence Modeling, 2016
A measure-of-cone representation of skewed continuous ln,p-symmetric distributions, n ∈ N, p > 0, is proved following the geometric approach known for elliptically contoured distributions.
Müller K., Richter W.-D.
doaj +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source

Measurement of charged-hadron distributions in heavy-flavor jets in proton-proton collisions at s = 13 $$ \sqrt{s}=13 $$ TeV

Journal of High Energy Physics
Charged-hadron distributions in heavy-flavor jets are measured in proton-proton collisions at a center-of-mass energy of s = 13 $$ \sqrt{s}=13 $$ TeV collected by the LHCb experiment.
The LHCb collaboration +1196 more
doaj +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source

Gluon GTMDs at nonzero skewness and impact parameter dependent parton distributions

European Physical Journal C: Particles and Fields
We investigate the leading twist generalized transverse momentum dependent parton distributions (GTMDs) of the unpolarized and longitudinally polarized gluons in the nucleon.
Chentao Tan, Zhun Lu
doaj +1 more source

Precise Optical Modeling of Phosphor-Converted LEDs With Arbitrary Concentration and Thickness Using Bidirectional Scattering Distribution Function

IEEE Photonics Journal, 2018
Phosphor-converted light-emitting diode (pcLED) is one of the most promising methods to generate white light. The interaction of the excitation light with the phosphor in pcLED is a complicated phenomenon, combining light absorption, light conversion ...
Jia-Sheng Li +5 more
doaj +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source

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