The current use of artificial light during the natural dark phase has acquired contaminant dimensions, known as “light pollution”. It is well known that exposure to dim light at night (dLAN) during the postnatal period severely impairs the ...
José Sarmiento +2 more
core +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Update on EPA lead mapping efforts to identify locations at higher risk of lead exposure [PDF]
EPA-mapping-efforts-locations-high-risk-lead-exposure-Dec-LEPAC-508 ...
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Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Natural Light Exposure as a Potential 7th Pillar of Lifestyle Medicine. [PDF]
Am J Lifestyle MedTremblay-Laliberté M, Tremblay A.
europepmc +1 more source
In this paper we examine the relationship between exchange rate movements and firm value. We estimate the exchange rate exposure of publicly listed firms in a sample of eight (non-US) industrialized and emerging markets, and find that a significant ...
Kathryn M.E. Dominguez, Linda L. Tesar
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Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Light exposure and sleep architecture in real-world settings. [PDF]
NPJ Biol Timing SleepAkgun SG +8 more
europepmc +1 more source
Lead Exposure and Prevention Advisory Committee (LEPAC) meeting : National Center for Environmental Health (NCEH), Centers for Disease Control and Prevention (CDC), December 3, 2021, 9:00 a.m. ET to 4:05 p.m. ET : meeting summary [PDF]
The Lead Exposure and Prevention Advisory Committee (LEPAC) convened on December 3, 2021. Remote participation through a virtual ZOOM meeting was used to hold the meeting.
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