Results 131 to 140 of about 24,825,488 (305)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Four-State Programmable Quasi-BIC Metasurface with Polarization-Divergent Dispersion Rewriting
PhotonicsA central challenge in reconfigurable photonics based on quasi bound states in the continuum (quasi-BICs) is to move beyond binary switching toward multistate and polarization-aware programmability.
Wenbin Wang, Yun Meng
doaj +1 more source
4D Anisotropic Diffusion Framework with PDEs for Light Field Regularization and Inverse Problems [PDF]
, 2019 International audienceIn this paper, we consider the problem of vector-valued regularization of light fields based on PDEs. We propose a regularization method operating in the 4D ray space that does not require prior estimation of disparity maps.
Guillemot, Christine +2 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Broadband Optical Edge Detection Based on Two-Dimensional Liquid Crystal Polarization Grating
PhotonicsA two-dimensional liquid crystal polarization grating (2D-LCPG) is realized by using a single-exposure photoalignment system. When using a horizontal polarized light as the reference incident light, four circular polarized light beams are captured with a
Ying Ma +4 more
doaj +1 more source
Proceedings of the ACM symposium on Virtual reality software and technology - VRST '02, 2002 We propose to look at light fields from a dual space point of view. The advantage, in addition to revealing some new insights, is a framework that combines the benefits of many existing works. Using the well known two-plane-parameterization, we derive the duality between the 4-D light field and the 3-D world space.
Chen, George +6 more
openaire +2 more sources
Kinematics and Selection Rules for Light-by-Light Scattering in a Strong Magnetic Field
, 2020 Selection rules that follow from parity and four-momentum conservation are listed for head-on light-by-light scattering in a strong magnetic field taking into account nontrivial dispersion laws of different photon eigen-modes.
Anatoly Shabad
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source