Results 141 to 150 of about 4,134,739 (261)
Robust Deviations from Signaling Equilibria [PDF]
In Sender-Receiver games with costly signaling, some equilibria are vulnerable to deviations which could be "unambiguously" interpreted by the Receiver as coming from a unique set of possible Sender-types.
Peter Eso, James Schummer
core
Plant CommunicationsThe initiation of light signaling involves the formation of phyB nuclear photobodies (PBs). The nuclear pore complex (NPC) is the sole gate for macromolecule transport between the cytoplasm and nucleus; however, its role in phyB PB formation and light ...
Yacong Wang +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2019 Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development.
Isabelle Sung +7 more
core +1 more source
PlantsSoil salinity is a major constraint on crop productivity, and plants rely on multilayered regulatory mechanisms to adapt to stress. Alternative splicing (AS) enhances transcriptome plasticity, yet how light modulates AS under salt stress remains unclear.
Yuanru Luo +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Interplay of light and nitrogen for plant growth and development
Crop JournalLight and nitrogen (N) are two critically environmental factors essential for plant survival, as they constitute the fundamental molecular framework of plant cells and significantly influence patterns of plant growth and development. Light is the driving
Chenlong Guan, Dong Zhang, Chengcai Chu
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Behind the scenes: the roles of light signaling in stomatal movements
Horticultural Plant JournalStomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment. They are crucial for photosynthesis, water use efficiency (WUE), and the plant’s ability to adapt to ...
Kangyou Zhu +14 more
doaj +1 more source