Results 71 to 80 of about 4,834,015 (307)
Precision Molding Simulation Study of 3D Ultra-Thin Glass Components for Smartwatches
MicromachinesHigh stress and shape deviation during the glass forming process often led to low yield rates, posing a challenge in the production of high-precision smartwatch components.
Xinfeng Zhao +3 more
doaj +1 more source
Which Gets Hotter, Land or Water? [PDF]
, 1999 This activity illustrates how dark land surfaces, light land surfaces and water all heat at different rates. Students determine whether land or water absorbs heat more quickly and how this difference affects weather and climate.
Christine McLelland
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
2007 Great Bay Organic Nitrogen and Light Extinction Monitoring Program [PDF]
, 2008 Nitrogen is most often considered to be the limiting nutrient for plant growth in marine waters. As a result, knowledge of nitrogen loading and ambient water-column concentrations are considered to be critical to understanding the response of aquatic ...
Pennock, Jonathan
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
2006 Great Bay Organic Nitrogen (PON & DON) and Light Extinction (PAR) Monitoring Program [PDF]
, 2006 Nitrogen is most often considered to be the limiting nutrient for plant growth in marine waters. As a result, knowledge of nitrogen loading and ambient water-column concentrations are considered to be critical to understanding the response of aquatic ...
Pennock, Jonathan
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
MoleculesAlpha-cembratriene-4,6-diol (α-CBT-diol) is a complex diterpenoid primarily found in Solanaceae (i.e., tobacco leaves), Pinaceae, and marine corals. Due to its intricate chemical structure, it serves as a precursor for several aroma compounds, including ...
Shen Huang +5 more
doaj +1 more source