Results 141 to 150 of about 783,623 (305)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Adapting PILOTE model for water and yield management under direct seeding system: The case of corn and durum wheat in a Mediterranean context [PDF]
Crop models are useful tools for integrating knowledge of biophysical processes governing the plant-soil-atmosphere system. But few of them are easily usable for water and yield management especially under specific cropping systems such as direct seeding.
J.C. Mailhol +3 more
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Conundrum or Complication: A Study of Yield Curve Dynamics under Unusual Economic Conditions and Monetary Policies. [PDF]
The definition of the decline of long term yields in the light of increasing short term yields as a conundrum by Chairman Greenspan in February 2005 has generated a significant amount of research.
David Edelman, Peter Cripwell
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Light-altering cover materials and sustainable greenhouse production of vegetables: a review
, 2021 Greenhouse horticulture (protected cropping) is essential in meeting increasing global food demand under climate change scenarios by ensuring sustainability, efficiency, and productivity.
He, X (15490340) +8 more
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
PlantsThis study aimed to investigate the effects of different light qualities on the morphological development, photosynthetic characteristics, stomatal structure, and yield of potato, providing theoretical and practical guidance for optimizing light ...
Rong Guo +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The green solar collector: optimization of microalgal areal productivity
, 2009 De Groene Zonnecollector (GZC) is een fotobioreactor die is ontworpen voor efficiënte teelt van microalgen op zonlicht. De zon wordt gevolgd door lenzen die het zonlicht op zogenaamde light guides focussen en waarin het licht reflecteerd en naar de algen
Zijffers, J.F.
core