Results 61 to 70 of about 3,193,855 (298)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
International Journal of Engineering Business Management, 2011 In China, the manufacturing of lighting products is very labour intensive. The approach used to check quality and control production relies on operators who test using various types of fixtures.
C.K. Ng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 1928 Colored catalog intended for customers purchasing lighting fixtures from the Acme Lighting Products company.Cover title.
Acme Lighting Products
core
Photometric measurements of lighting quality: an overview [PDF]
, 2018 This paper aims to provide an overview of various aspects used to measure the overall lighting quality, instead of solely focusing on a single aspect. Lighting quality is a concept that allows excellent vision while providing high comfort.
Rajendra Dangol +8 more
core +3 more sources
An investigation of the role of artificial lighting in the process of creating a pleasant affective spacial meaning: A case study of Dahd Hotel in Yazd [PDF]
کاوشهای جغرافیایی مناطق بیابانی, 2020 Due to its being located in a desert area, the city of Yazd has a favorable weather and a clear starry sky at nighttime. So, has the potential to expand nightlife and become a "24-hour city".
Neda Khaksar +2 more
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Determining the Difference between Predicted vs. Actual Lighting Use in Higher Education Corridors
Frontiers in Mechanical Engineering, 2017 The performance gap is a measure of the difference between design assumptions and actual in field data. Estimating terms, specifically the operational hours of use, when making such design assumptions in order to predict the impact of lighting upgrades ...
Katharine L. van Someren +2 more
doaj +1 more source