Results 41 to 50 of about 3,193,855 (298)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Energy efficient innovative lighting and energy supply solutions in developing countries [PDF]

, 2007
The vast majority of the rural population in the de veloping countries is out of reach of electricity and hence has to depend on the tradi tional fuels to fulfil the daily energy needs.
Halonen, L., Eloholma, M., Zahnd, A., Bhusal, P.   +3 more
core  

Switchable thermoelectric cooler with radial heatsink for dual-mode thermal management system

Results in Engineering
As futuristic mobility advances, the importance of light-emitting diode (LED) lighting systems is growing, emphasizing the need for advanced, energy-efficient cooling systems.
Yu Rim Kang, Sang Hun Lee, Yoon-Chul Lee, Chang-Ju Park, Yangkyu Park   +4 more
doaj   +1 more source

A multi-criteria decision making approach in lighting technology selection for a production hall

MATEC Web of Conferences, 2018
Nowadays, lighting industry can contribute to a more sustainable future, by reducing the total consumption of electrical energy used to illuminate indoor and outdoor spaces.
Cristea Maria, Adrian Tîrnovan Radu, Cristea Ciprian, Sorin Pică Constantin   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Energy-neutral solar-powered street lighting with predictive and adaptive behaviour [PDF]

, 2014
Street lighting can enhance the safety and security of residential and commercial areas. However, its installation and operation is expensive: cables must be installed, and power is drawn from the grid which is typically dominated by non-renewable ...
Geoff V. Merrett, Weddell, Alex S., Merrett, Geoff V., Sei Ping Lau, Neil M. White, Alex S. Weddell, Lau, Sei Ping, White, NM   +7 more
core   +1 more source

Key Factors Dictating Excessive Lighting Energy Consumption in Schools: a Post-Occupancy Analysis

Journal of Sustainable Design and Applied Research in Innovative Engineering of the Built Environment, 2017
Good practice in lighting energy consumption in schools is regarded to be around 13 kWh/m2 per annum (CIBSE LG5, 2011). However, recent post-occupancy evaluations reveal lighting energy consumption in schools to be above 30kWh/m2 p.a., despite the use of
Peter Raynham, Roderic Bunn
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source