Results 51 to 60 of about 160,406 (310)

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Importance of Lightning Activity Monitoring Systems for Transmission Line Lightning Performance Improvement Studies

B&H Electrical Engineering, 2020
Abstract Line surge arresters are mainly used for transmission line lightning performance improvement. Calculation of energy stresses of lines surge arrester is of extreme importance for the selection of the arrester class. Energy stresses of transmission line surge arresters due to multicomponent lightning flashes are analysed in this ...
Selma Grebović, Mirza Batalović, Adis Balota, Nermin Oprašić   +3 more
openaire   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Analysis of Spatio-Temporal Variability of Lightning Activity and Wildfires in Western Siberia during 2016–2021

Atmosphere, 2022
This research compares the spatial and temporal variability of lightning activity associated with wildfires in several natural geographical zones of Western Siberia from 2016–2021.
Elena Kharyutkina, Konstantin Pustovalov, Evgeniia Moraru, Olga Nechepurenko   +3 more
doaj   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Controls on interannual variability in lightning-caused fire activity in the western US

Environmental Research Letters, 2016
Lightning-caused wildfires account for a majority of burned area across the western United States (US), yet lightning remains among the more unpredictable spatiotemporal aspects of the fire environment and a challenge for both modeling and managing fire ...
John T Abatzoglou, Crystal A Kolden, Jennifer K Balch, Bethany A Bradley   +3 more
doaj   +1 more source

Very low latitude (L = 1.08) whistlers and correlation with lightning activity [PDF]

, 2015
We present analysis of more than 2000 lightning-generated whistlers recorded at a low-latitude station, located at Allahabad (geographic latitude, 25.40N; geographic longitude, 81.93E; L = 1.081), India, during December 2010 to November 2011.
Cohen, M.B., Gokani, S.A., Kumar, S., Lichtenberger, János, Singh, Rajesh, Venkatesham, K.   +5 more
core   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Thunderstorm total lightning activity behavior associated with transmission line trip events of power system

npj Climate and Atmospheric Science
High-voltage transmission lines are susceptible targets for lightning strikes. It is an interesting topic how the trip event of transmission line is related to the area, location, and intensity of thunderstorms occurring at that time and that place ...
Muzi Li, Si Cheng, Jianguo Wang, Li Cai, Yadong Fan, Jinxin Cao, Mi Zhou   +6 more
doaj   +1 more source

Hurricane Irma 2017: Relationships with Lightning, Gravity, and Earthquakes (Update – Coronal Holes and Hurricane Dorian 2019) [PDF]

Journal of Systemics, Cybernetics and Informatics, 2020
Hurricane Irma, 2017, along with other storm systems (Fig. 1) howling winds and grounding lightning (Fig. 2), tracked Caribbean mantle circuits along the tectonic trenches of Puerto Rico and Cuba.
Bruce Leybourne
doaj