Results 51 to 60 of about 57,668 (300)

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Huntsville Alabama Marx Meter Array 2: Upgrade and Capability

Earth and Space Science, 2020
The Córdoba Argentina Marx Meter Array (CAMMA), consisting of 10 second‐generation Huntsville Alabama Marx Meter Array (HAMMA 2) sensors, operated at Córdoba, Argentina, during the Remote sensing of Electrification, Lightning, And Mesoscale/microscale ...
Yanan Zhu, Phillip Bitzer, Michael Stewart, Scott Podgorny, David Corredor, Jeff Burchfield, Lawrence Carey, Bruno Medina, Michael Stock   +8 more
doaj   +1 more source

Electrical conductivity of carbon nanofiber reinforced resins: potentiality of Tunneling Atomic Force Microscopy (TUNA) technique [PDF]

, 2003
Epoxy nanocomposites able to meet pressing industrial requirements in the field of structural material have been developed and characterized. Tunneling Atomic Force Microscopy (TUNA), which is able to detect ultra-low currents ranging from 80 fA to 120 ...
Raimondo1, Marialuigia, Guadagno, Liberata, Vertuccio, Luigi, Naddeo, Carlo, Barra, Giuseppina, Spinelli, Giovanni, Lamberti, Patrizia, Tucci, Vincenzo, Lafdi, Khalid   +8 more
core   +3 more sources

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Characteristics of broadband lightning emissions associated with terrestrial gamma ray flashes [PDF]

, 2011
To characterize lightning processes that produce terrestrial gamma ray flashes (TGFs), we have analyzed broadband (
Cummer, Steven A., Grefenstette, Brian W., Han, Feng, Li, Jingbo, Lu, Gaopeng, Smith, David M.   +5 more
core   +2 more sources

Mapping the Lateral Development of Lightning Flashes From Orbit [PDF]

Journal of Geophysical Research: Atmospheres, 2018
AbstractOptical lightning measurements from the Lightning Imaging Sensor (LIS) are used to map the lateral development of lightning flashes and produce statistics that describe their motion through the electrified cloud. This is accomplished by monitoring the frame‐by‐frame (group‐level) evolution of the optical signals produced during each flash ...
Michael Peterson, Scott Rudlosky, Wiebke Deierling   +2 more
openaire   +2 more sources

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Citizen Science Observation of a Gamma‐Ray Glow Associated With the Initiation of a Lightning Flash

Geophysical Research Letters, 2023
Gamma‐ray glows are observational evidence of relativistic electron acceleration due to the electric field in thunderclouds. However, it is yet to be understood whether such relativistic electrons contribute to the initiation of lightning discharges.
M. Tsurumi, T. Enoto, Y. Ikkatai, T. Wu, D. Wang, T. Shinoda, K. Nakazawa, N. Tsuji, G. S. Diniz, J. Kataoka, N. Koshikawa, R. Iwashita, M. Kamogawa, T. Takagaki, S. Miyake, D. Tomioka, T. Morimoto, Y. Nakamura, H. Tsuchiya   +18 more
doaj   +1 more source

Characteristics of Lightning Activities over the Tibetan Plateau Based on Satellite Detection and Its Circulation Background Analysis

Atmosphere, 2023
Based on the detection data obtained by the LMI (Lightning Mapping Imager)—China’s first satellite-based lightning observation payload—from 2018–2022, combined with the ERA5 (ECMWF Reanalysis v5) reanalysis data of the same period, the temporal and ...
Jie Zhu, Shulin Zhi, Suling Ren
doaj   +1 more source