Results 51 to 60 of about 1,245,017 (279)

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

A New Approach of 3D Lightning Location Based on Pearson Correlation Combined with Empirical Mode Decomposition

Remote Sensing, 2021
To improve the accuracy of pulse matching and the mapping quality of lightning discharges, the Pearson correlation method combined with empirical mode decomposition (EMD) is introduced for discharge electric field pulse matching.
Yanhui Wang, Yingchang Min, Yali Liu, Guo Zhao   +3 more
doaj   +1 more source

Smart CMOS image sensor for lightning detection and imaging [PDF]

, 2013
We present a CMOS image sensor dedicated to lightning detection and imaging. The detector has been designed to evaluate the potentiality of an on-chip lightning detection solution based on a smart sensor.
Goiffon, Vincent, Rolando, Sébastien, Molina, Romain, Guiry, Saïprasad, Tulet, Michel, Corbière, Franck, Larnaudie, Franck, Bréart-de-Boisanger, Michel, Leone, Bruno, Perez-Cuevas, Leticia, Saint-Pé, Olivier, Magnan, Pierre, Zayer, Igor   +12 more
core   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Huntsville Alabama Marx Meter Array 2: Upgrade and Capability

Earth and Space Science, 2020
The Córdoba Argentina Marx Meter Array (CAMMA), consisting of 10 second‐generation Huntsville Alabama Marx Meter Array (HAMMA 2) sensors, operated at Córdoba, Argentina, during the Remote sensing of Electrification, Lightning, And Mesoscale/microscale ...
Yanan Zhu, Phillip Bitzer, Michael Stewart, Scott Podgorny, David Corredor, Jeff Burchfield, Lawrence Carey, Bruno Medina, Michael Stock   +8 more
doaj   +1 more source

Spatial distribution and frequency of lightning activity and lightning flash density maps for Australia [PDF]

Journal of Geophysical Research: Atmospheres, 2006
The spatial distribution and frequency of lightning activity in Australia have been analyzed using lightning data obtained by ground‐based lightning detection instruments denoted CIGRE‐500 and CGR3 and by NASA satellite‐based instruments denoted OTD and LIS.
Kuleshov, Yuriy, Mackerras, David, Darveniza, Mat   +2 more
openaire   +4 more sources

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Rapid Sampling and Polarimetric Statistics of Lightning With a Phased Array Radar

Geophysical Research Letters
Previous studies of lightning detection by radar mostly consisted of observations with reflector‐antenna systems yielding slow volume scan times.
Vitor Goede, David Schvartzman, David Bodine, Vanna C. Chmielewski, Tian‐You Yu, Eric Bruning, Min‐Duan Tzeng, Michael Stock   +7 more
doaj   +1 more source