Results 91 to 100 of about 828,317 (269)

Using the Genetic Algorithm to Maximize the Likelihood Function of Normal Distribution [PDF]

المجلة العراقية للعلوم الاحصائية, 2008
In this research, the genetic algorithm (GA) has been carried out. This application is considered to be a manufacturing treatment to find the value which maximizes the likelihood function . An algorithm has been proposed to find the values which maximize.
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Maximum Likelihood Time Delay Estimation Based on Monte Carlo Importance Sampling in Multipath Environment

International Journal of Antennas and Propagation, 2017
In multipath environment, the computation complexity of single snapshot maximum likelihood for time delay estimation is huge. In particular, the computational complexity of grid search method increases exponentially with the increase of dimension.
Bin Ba, Weijia Cui, Daming Wang, Jianhui Wang   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Interval Estimation from the Likelihood Function

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1971
Summary During the last few years, several authors have devoted attention to both old and new methods of making inferences from likelihood functions. In this paper we study the properties of interval estimates which are obtained by drawing a horizontal line across the graph of the likelihood function.
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Occluded building height estimation from single HR SAR image based on an iterative model matching technique

Tongxin xuebao, 2013
Based on the analysis of occluded buildings in high resolution SAR images, a novel method for occluded building height estimation was proposed. First, a projection model for SAR building signature prediction from a 3D pa-rametric model was constructed ...
Li-bing JIANG, Zhuang WANG, Lin LEI, Wen-xian YU   +3 more
doaj  

Towards the mother-of-all-models: customised construction of the mark-recapture likelihood function

Animal Biodiversity and Conservation
Hacia el origen de todos los modelos: una construcción personalizada de la función de verosimilitud en los estudios de marcaje–recaptura Dada la proliferación de modelos de marcaje–recaptura y de los estudios que recopilan datos al respecto, los ...
R. J. Barker, G. C. White
doaj   +1 more source