Results 241 to 250 of about 38,309 (309)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Endostemonine I as a Multi-Target Inhibitor of Kaposi's Sarcoma-Associated Herpesvirus Oncogenic Pathways: An Integrative Computational Study. [PDF]

Med Sci (Basel)
Sama-Ae I, Daloh M, Tedasen A, Changrob S, Lertcanawanichakul M, Kwankaew P, Issaro P, Maidam N, Rattanapong N, Auma N, Kaseng M, Tayeh M.   +11 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

<i>Withania somnifera</i> Root Extract Ameliorates PTU-Induced Hypothyroidism by Regulating Hormone Levels and Gene Expression in Rats. [PDF]

Food Sci Nutr
Hossain MS, Shuvo MSP, Talukder MMH, Shahidullah, Jannat S, Niaz SMR, Sohel M, Islam MK.   +7 more
europepmc   +1 more source

Bioinformatics and computational exploration of novel inhibitors targeting KRAS G12C mutant protein in lung adenocarcinoma. [PDF]

Discov Oncol
Tang G, Ding H, Gong Y.
europepmc   +1 more source

Application of Reinforcement Learning Techniques in De Novo Drug Design: A Systematic Literature Review. [PDF]

Health Sci Rep
Sampa MB, Aziz NHA.
europepmc   +1 more source

Exploring imidazo[1,2-a]pyridine hybrids in cancer therapy: ADMET profiling, molecular docking, MD simulations and DFT calculations. [PDF]

Sci Rep
Shah D, Nagani A, Shah M, Patel A.
europepmc   +1 more source

In vitro and in silico characterization of Crocatin A from red betel leaves: targeting DNA gyrase B and DNA ligase of Enterococcus faecalis with ADMET-based druglikeness analysis. [PDF]

BMC Chem
Meliani D, Yuliana T, Kurnia D.
europepmc   +1 more source

Design and Biological Profiling of a Drug-like Chloropyridine Diamine as a Dual Antioxidant-Antimicrobial Lead: In Vitro Evaluation and In Silico Multi-Target Studies. [PDF]

Int J Mol Sci
Merzouki O, Ech-Chihbi E, Arrousse N, Mabrouk EH, Hefnawy M, Fernine Y, El-Gendy M, Taleb M.   +7 more
europepmc   +1 more source