Results 231 to 240 of about 169,955 (305)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

In Silico Screening of Plant-Derived Termiticidal Compounds Targeting Cytochrome P450 in <i>Coptotermes</i> spp. (Blattodea: Rhinotermitidae) for Sustainable Termite Management. [PDF]

Plants (Basel)
Mahanta DK, Bhoi TK, Jangra S.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

APPi: A Multiscale Qualitative-Quantitative Insecticide-Likeness Evaluation Platform and Application. [PDF]

Plant Biotechnol J
Cui JL, He Q, Jin BY, Sun XP, Li H, Wei Y, Zhang XM, Zhang L.   +7 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Developing a Service Quality Index System for AI Health Care Chatbots: Mixed Methods Study.

J Med Internet Res
Gu Y, Wang X.
europepmc   +1 more source

Uncovering the antiproliferative potential of Lobophytum pauciflorum metabolites through chemoinformatics and in vitro approaches. [PDF]

Sci Rep
Alassass AA, Abu Bakr MS, Mahmoud AA, Eid MM, Ayyad SN, Mohammed AEI.   +5 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Identifying Key Metabolites in South African Medicinal Plants Using Dual Electrospray Ionization Metabolomics. [PDF]

Plants (Basel)
Makhafola MA, Naidoo CM, Obi CL, Iweriedor BC, Olaokun OO, Prinsloo E, Zubair MS, Mkolo NM.   +7 more
europepmc   +1 more source

Identification of a Novel Trifluoromethyl-Bearing Flavonoid as a Promising Androgen Receptor Antagonist: Structure-Based Virtual Screening and In Vitro Study. [PDF]

Comput Struct Biotechnol J
Tadasee P, Khotavivattana T, Chaithirayanon K, Assawakosri S, Nutho B.   +4 more
europepmc   +1 more source