Results 211 to 220 of about 49,716 (300)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A pro-natural product design strategy affords ester-based green fungicide candidates. [PDF]

Sci Adv
Lei P, Yuan H, Lu X, Sun T, Qu Y, Wang L, Dai T, Miao J, Gao Y, Liu X.   +9 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Metabolic Screening and In Silico Investigation of Eucalyptus globulus Essential Oil Bioactives Against DENV-2 Envelope Protein. [PDF]

ChemistryOpen
Afzal A, Ahmad I, Mahadullah, Qamar S, Yousaf T, Ullah F, Khan D, Hamdard MH, Mashwani ZUR.   +8 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Antibacterial and Multi-Target Immunomodulatory Mechanisms of Marine <i>Nocardia rhizosphereae</i> Metabolites: Experimental and Network Pharmacology. [PDF]

Microorganisms
Maliehe TS, Shekwa W, Pooe OJ, Masoko P.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Autonomous bioisosteric replacement for multi-property optimization in drug design. [PDF]

Nat Commun
Kim H, Moon S, Zhung W, Kim S, Lim J, Kim WY.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Identification of Small-Molecule Inhibitors of <i>Babesia bovis</i> by High-Throughput SYBR Green I Screening. [PDF]

Pharmaceuticals (Basel)
Miruka SA, Ariefta N, Guswanto A, Fathi A, Lee JS, Komatsu K, Suganuma K, Yokoyama N, Nishikawa Y, Asada M.   +9 more
europepmc   +1 more source