Results 61 to 70 of about 894,945 (299)
The silence of the limbs [PDF]
Cardiovascular Research, 2011 This editorial refers to ‘Silencing of Int6 gene restores function of the ischaemic hindlimb in a rat model of peripheral arterial disease’ by N. Okamoto et al ., pp. 209–217, this issue. Okamoto et al. 1 report that Int6 levels are reduced by direct administration of silencing small-interfering RNA (siRNA) into the hindlimb (adductor) muscles ...
Eileen M, Denovan-Wright +1 more
openaire +2 more sources
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
HoxA Genes and the Fin-to-Limb Transition in Vertebrates
Journal of Developmental Biology, 2016 HoxA genes encode for important DNA-binding transcription factors that act during limb development, regulating primarily gene expression and, consequently, morphogenesis and skeletal differentiation. Within these genes, HoxA11 and HoxA13 were proposed to
João Leite-Castro +3 more
doaj +1 more source
Orthopaedic Surgery, 2023 Objective Complications related to triceps after total elbow arthroplasty (TEA) have become a major surgical concern. The triceps‐preserving approach has the advantage of not disturbing the insertion of triceps but is disadvantaged by the reduced ...
Qing Zhang +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe +7 more
wiley +1 more source
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
Optimising the prescription and use of lower limb prosthetic technology: a mixed methods approach [PDF]
, 2010 Aim: Lower limb amputation is an increasingly prevalent surgical procedure in the Western world due to the increase of peripheral vascular disease. Not everyone who receives a prosthetic limb will benefit from its use and may abandon this expensive ...
Schaffalitzky, Elisabeth Manon
core +2 more sources
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source
A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors
Cell Reports, 2017 Mammals have extremely limited regenerative capabilities; however, axolotls are profoundly regenerative and can replace entire limbs. The mechanisms underlying limb regeneration remain poorly understood, partly because the enormous and incompletely ...
Donald M. Bryant +21 more
doaj +1 more source