Results 141 to 150 of about 699,259 (402)

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Racial Differences in the Effect of Granulocyte Macrophage Colony-Stimulating Factor on Improved Walking Distance in Peripheral Artery Disease: The PROPEL Randomized Clinical Trial. [PDF]

, 2019
Background The effects of race on response to medical therapy in people with peripheral artery disease ( PAD ) are unknown. Methods and Results In the PROPEL (Progenitor Cell Release Plus Exercise to Improve Functional Performance in PAD) Trial, PAD ...
Criqui, Michael H, Domanchuk, Kathryn, Ferrucci, Luigi, Guralnik, Jack M, Kibbe, Melina R, Li, Lingyu, McDermott, Mary M, Polonsky, Tamar S, Stein, James, Taylor, Doris A, Tian, Lu, Zhao, Lihui   +11 more
core   +1 more source

Saving life and limb: limb salvage using external fixation, a multi-centre review of orthopaedic surgical activities in Médecins Sans Frontières

International Orthopaedics, 2014
PurposeWhile the orthopaedic management of open fractures has been well-documented in developed settings, limited evidence exists on the surgical outcomes of open fractures in terms of limb salvage in low- and middle-income countries.
M.J.L. Bertol, R. Van den Bergh, M. T. Trelles Centurion, Hyacinthe Kenslor Ralph D, Jean-Paul Basimuoneye Kahutsi, Abdul Qayeum Qasemy, J. Jean, Alberta Majuste, Theophile Kubuya Hangi, S. Safi   +9 more
semanticscholar   +1 more source

From Origami to Bistable and Laminate Structures: A Review for Multifunctional Applications from Structural Perspective of Shape‐Changing Structures

Advanced Intelligent Systems, EarlyView.
This review explores how shape‐changing structures—origami, bistable, and laminate structures—enable multifunctionality in soft robotics and metamaterials. Starting from structural design, it examines core principles, real‐world applications, and ongoing challenges.
Lingchen Kong, Yaoyao Fiona Zhao
wiley   +1 more source

Validity of Mangled Extremity Score System to Predict Limb Salvage on Cases of Traumatic Popliteal Artery Injuries: A Case Series and Review of the Literature

, 2023
Amr A. Mahmoud, Mohamed AbdelSamie Abdelkhalek Elbahat   +1 more
openalex   +2 more sources

Bio‐to‐Robot Transfer of Fish Sensorimotor Dynamics via Interpretable Model

Advanced Intelligent Systems, EarlyView.
This study demonstrates how a biologically interpretable model trained on real‐fish muscle activity can accurately predict the motion of a robotic fish. By linking real‐fish sensorimotor dynamics with robotic fish, the work offers a transparent, data‐efficient framework for transferring biological intelligence to bioinspired robotic systems.
Waqar Hussain Afridi, Ahsan Tanveer, Rahdar Hussain Afridi, Muhammad Hamza, Mingxin Wu, Liang Li, Guangming Xie   +6 more
wiley   +1 more source

ControlIt: A Universal Framework for Translational, Adaptive, and Online Brain–Computer Interfaces

Advanced Intelligent Systems, EarlyView.
Brain–computer interfaces (BCIs) lack a unified platform that works across signals and algorithms. ControlIt, an open‐source, modular ROS2‐based BCI framework supporting electroencephalography (EEG), electrocorticography (ECoG), and spike‐based decoding across both classification and regression tasks is presented.
Wanlin Yang, Chenyang Li, Xinxiu Xu, Xindong Wang, Yongcheng Guo, Xiaoke Chai, Tianqin Cao, Jiuxiang Song, Nan Wang, Xueming Zhang, Yi Yang, Cong Zheng, He Cui   +12 more
wiley   +1 more source

Refractory compartment syndrome after antivenom administration for an Eastern Diamondback Rattlesnake bite requiring fasciotomy for limb salvage: A case report

, 2023
Daniel R. Cavazos, Rebecca Schultz, Devan O. Higginbotham, Joshua Goethals, Rahul Vaidya   +4 more
openalex   +1 more source

Salvage of the lower limb

Journal of British Surgery, 1976
Abstract This is a retrospective study of 80 patients with 94 severely ischaemic lower limbs treated over a period of' 6 years. Arterial reconstruction was possible in 47 patients (54 limbs) and 76 per cent of' these limbs were salvaged. There was no operative mortality.
openaire   +2 more sources

The Diagnosis That Arrived Decades Late: Living Without and Then With Myhre Syndrome

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MIM #139210) is a rare multisystem disorder first described in 1981, characterized by short stature, neurodevelopmental delay, joint contractures, and cardiopulmonary complications. Its molecular basis, recurrent pathogenic variants in SMAD4, was not discovered until 2011. This narrative is based on a review of medical records,
Abdallah F. Elias
wiley   +1 more source