Results 61 to 70 of about 6,717 (307)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

open access: yesAdvanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu   +11 more
wiley   +1 more source

Limb salvage surgery in extreme situations of prosthetic complications [PDF]

open access: yes, 2017
The treatment of periprosthetic hip and knee infection associated with loss of bone substance, as well as the treatment of the infection of large structural allografts used in tumoral reconstructive surgery, are a major challenge to the orthopaedic ...
Casanova, J   +6 more
core  

Review of Osteosarcoma and Current Management [PDF]

open access: yes, 2016
Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma.
Hue H. Luu   +2 more
core   +1 more source

3D Bioprinting in Limb Salvage Surgery

open access: yesJournal of Functional Biomaterials
With the development of 3D bioprinting and the creation of innovative biocompatible materials, several new approaches have brought advantages to patients and surgical teams. Increasingly more bone defects are now treated using 3D-bioprinted prostheses and implementing new solutions relies on the ability of engineers and medical teams to identify ...
Iosif-Aliodor Timofticiuc   +8 more
openaire   +3 more sources

Limb salvage surgery for osteosarcoma

open access: yesIndian Journal of Orthopaedics, 2014
While limb salvage surgery has long been established as the standard of care for osteosarcoma, large studies from Indian centers are few. Given the diverse socio economic milieu of our patients, it becomes significant to determine the feasibility and outcome of management of osteosarcoma in our population.
Tiwari, Akshay   +5 more
openaire   +3 more sources

Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era

open access: yesAdvanced Science, EarlyView.
This review provides detailed information on modern cytoprotective strategies for ischemic stroke in the context of recanalization therapies. It derives their rationale based on contemporary knowledge of stroke pathophysiology and discusses the role of advanced imaging approaches as well as concepts for novel clinical trial designs.
Johannes Boltze, Marc Fisher
wiley   +1 more source

Regional anaesthesia-based free flap reconstruction for limb salvage in high-risk patients with refractory lower limb infections

open access: yesJPRAS Open
Background: Patients with severe comorbidities and refractory lower leg and foot infections face high risks from prolonged anaesthesia and complex soft tissue reconstruction.
Mitsutoshi Ota   +5 more
doaj   +1 more source

Validation of mangled extremity severity score in assessing the need for extremity amputation

open access: yesNigerian Journal of Medicine, 2017
INTRODUCTION: The decision to either salvage or amputate a mangled extremity poses great challenge to a surgeon.Different scoring systems were therefore developed to aid orthopaedic surgeons in this decision,eitherto contemplate amputation or proceed to ...
B A Okechukwu   +3 more
doaj   +1 more source

a retrospective study [PDF]

open access: yes, 2014
Introduction Emergency treatment of major sub-/total traumatic amputations continue to represent a clinical challenge due to high infection rates and serious handicaps.
Giesecke, Moritz T.   +4 more
core   +1 more source

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