Results 51 to 60 of about 17,324,907 (200)

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Cerebral Anatomy of the Spider Monkey Ateles Geoffroyi Studied Using Magnetic Resonance Imaging. First Report: a Comparative Study with the Human Brain Homo Sapiens [PDF]

Revista Ciencias de la Salud, 2009
The objective of the present qualitative studywas to analyze the morphological aspects of theinner cerebral anatomy of two species of primates,using magnetic resonance images (MRI):spider monkey (A.
Fernando Chico-Ponce de León, Diana Platas-Neri, Jairo Muñoz-Delgado, Ana María Santillán-Doherty, Rita Arenas-Rosas, David Trejo, Rubén Conde, Rafael Ojeda-Flores, Aurelio Campos-Romo,, Eduardo Castro-Sierra, Juan José Cervantes, Marc Braun   +11 more
doaj  

Ongoing Secondary Degeneration of the Limbic System in Patients With Ischemic Stroke: A Longitudinal MRI Study

Frontiers in Neurology, 2019
Purpose: Ongoing post-stroke structural degeneration and neuronal loss preceding neuropsychological symptoms such as cognitive decline and depression are poorly understood.
Muhammad E. Haque, Refaat E. Gabr, Khader M. Hasan, Sarah George, Octavio D. Arevalo, Alicia Zha, Susan Alderman, Jerome Jeevarajan, Manual F. Mas, Xu Zhang, Nikunj Satani, Elliott R. Friedman, Clark W. Sitton, Sean Savitz   +13 more
doaj   +1 more source

Brain tissue properties differentiate between motor and limbic basal ganglia circuits [PDF]

, 2014
Despite advances in understanding basic organizational principles of the human basal ganglia, accurate in vivo assessment of their anatomical properties is essential to improve early diagnosis in disorders with corticosubcortical pathology and optimize ...
Haynes, J., Weiskopf, N, Ettore A. Accolla, Dukart, J., Kherif, Ferath, Weiskopf, N. ; https://orcid.org/, Kuehn, Andrea A., Helms, Gunther, Gunther Helms, Weiskopf, Nikolaus, Rumana Chowdhury, John‐Dylan Haynes, Chowdhury, R., Dukart, Jürgen, Draganski, Bogdan, Stefan Hetzer, Hetzer, S, Kühn, Andrea A., Draganski, B. ; https://orcid.org/, Accolla, E., Haynes, John-Dylan, Ferath Kherif, Juergen Dukart, Kühn, AA, Accolla, Ettore A., Chowdhury, R, Andrea A. Kühn, Dukart, Juergen, Chowdhury, Rumana, Hetzer, Stefan, Antoine Lutti, Hetzer, S., Lutti, Antoine, Accolla, EA, Draganski, B, Helms, Gunther,, Nikolaus Weiskopf, Kühn, A., Bogdan Draganski, Kherif, F., Kherif, F, Helms, G., Helms, G, Lutti, A, Lutti, A., Lund University., Dukart, J, Haynes, J-D   +47 more
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Wired for behavior: from development to function of innate limbic system circuitry

Frontiers in Molecular Neuroscience, 2012
The limbic system of the brain regulates a number of behaviors that are essential for the survival of all vertebrate species including humans.
Katie eSokolowski, Joshua G Corbin
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source