Results 141 to 150 of about 366,422 (303)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Equilibrium Political Budget Cycles [PDF]
Prior to elections, governments (at all levels) frequently undertake a consumption binge. Taxes are cut, transfers are raised, and government spending is distorted towards highly visible items. The "political business cycle" (better be thought of as "the
Kenneth Rogoff
core
The number of limit cycles of Josephson equation
, 2023 In this paper, the existence and number of non-contractible limit cycles of the Josephson equation $\beta \frac{d^{2}\Phi}{dt^{2}}+(1+\gamma \cos \Phi)\frac{d\Phi}{dt}+\sin \Phi=\alpha$ are studied, where $\phi\in \mathbb S^{1}$ and $(\alpha,\beta,\gamma)
Liu, Changjian +2 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Limit cycles in piecewise quadratic Kolmogorov systems [PDF]
Altres ajuts: acords transformatius de la UABWe study planar piecewise quadratic differential systems of Kolmogorov type. Specifically, we consider systems with both coordinate axes invariant and with a separation line that is straight and distinct from ...
Oliveira, Regilene +2 more
core +1 more source
Limit cycles in models of circular gene networks regulated by negative feedback loops. [PDF]
BMC Bioinformatics, 2020 Likhoshvai VA +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Limit cycles in discontinuous piecewise linear systems
, 2018 Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPqIn this work we will study limit cycles in piecewise smooth linear systems.
Silva, Ana Maria Alves da
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Algebraic limit cycles in piecewise linear differential systems
, 2021 This paper is devoted to study the algebraic limit cycles of planar piecewise linear differential systems. In particular we present examples exhibiting two explicit hyperbolic algebraic limit cycles, as well as some 1-parameter families with a saddle ...
Buzzi, Claudio. +2 more
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Existence and stability of limit cycles in the model of a planar passive biped walking down a slope. [PDF]
Proc Math Phys Eng Sci, 2020 Makarenkov O.
europepmc +1 more source