Results 71 to 80 of about 366,422 (303)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Small Amplitude Limit Cycles for Cubic Systems

open access: yes, 1993
In this article we study the simultaneous generation of limit cycles out of singular points and infinity for the family of cubic planar systemsWith a suitable choice of parameters, the origin and four other singularities are foci and infinity is a ...
E. Sáez, I. Szántó, V. Guíñez
core   +1 more source

Hopf Bifurcation of Limit Cycles in Discontinuous Liénard Systems

open access: yesAbstract and Applied Analysis, 2012
We consider a class of discontinuous Liénard systems and study the number of limit cycles bifurcated from the origin when parameters vary. We establish a method of studying cyclicity of the system at the origin.
Yanqin Xiong, Maoan Han
doaj   +1 more source

Limit cycles for a class of polynomial differential systems

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2016
In this paper, we consider the limit cycles of a class of polynomial differential systems of the form $\dot{x}=-y^{2p-1},\ \dot{y}=x^{2mp-1}+\varepsilon(px^{2mp}+qy^{2p})(g(x,y)-A)$, where $g(x,y)$ is a polynomial.
Jianyuan Qiao, Shuliang Shui
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Detecting limit cycles in stochastic time series

open access: yes, 2022
The emergence of oscillatory behaviour represents fundamental information about the interactions of the underlying system. In biological systems, oscillations have been observed in experimental data, but due to the significant level of noise, it is ...
Mathias S. Heltberg   +5 more
core   +1 more source

Nine Limit Cycles in a 5-Degree Polynomials Liénard System

open access: yesComplexity, 2020
In this article, we study the limit cycles in a generalized 5-degree Liénard system. The undamped system has a polycycle composed of a homoclinic loop and a heteroclinic loop.
Junning Cai, Minzhi Wei, Hongying Zhu
doaj   +1 more source

REDUCE and the bifurcation of limit cycles

open access: yesJournal of Symbolic Computation, 1990
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Noel G. Lloyd, Jane M. Pearson
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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