Results 81 to 90 of about 1,292,705 (285)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Nine Limit Cycles in a 5-Degree Polynomials Liénard System
Complexity, 2020 In this article, we study the limit cycles in a generalized 5-degree Liénard system. The undamped system has a polycycle composed of a homoclinic loop and a heteroclinic loop.
Junning Cai, Minzhi Wei, Hongying Zhu
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Limit cycles bifurcations of Liénard system with a hyperelliptic Hamiltonian of degree five
Electronic Journal of Qualitative Theory of Differential EquationsWe deal with limit cycles bifurcating from the period annulus of Liénard system with a hyperelliptic Hamiltonian of degree five under quartic perturbation, where Liénard system has a normal form $\dot{x}=y$, $\dot{y}=x(x-1)(x^{2}+ax+b)$, $a^{2 ...
Yi Shao, Chunxiang A
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Center conditions and limit cycles for BiLienard systems
Electronic Journal of Differential Equations, 2017 In this article we study the center problem for polynomial BiLienard systems of degree n. Computing the focal values and using Grobner bases we find the center conditions for such systems for n=6.
Jaume Gine
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Bifurcation of limit cycles from quartic isochronous systems
Electronic Journal of Differential Equations, 2014 This article concerns the bifurcation of limit cycles for a quartic system with an isochronous center. By using the averaging theory, it shows that under any small quartic homogeneous perturbations, at most two limit cycles bifurcate from the period ...
Linping Peng, Zhaosheng Feng
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