Results 101 to 110 of about 5,522,817 (294)

Lateral Bearing Capacity of Modified Suction Caissons Determined by Using the Limit Equilibrium Method

China Ocean engineering, 2018
The modified suction caisson (MSC) adds a short-skirted structure around the regular suction caissons to increase the lateral bearing capacity and limit the deflection.
Dayong Li, Shili Ma, Yukun Zhang, Fu-quan Chen   +3 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

A limit equilibrium fracture zone model to investigate seismicity in coal mines

International Journal of Mining Science and Technology, 2018
This paper explores possible synergies between techniques used to minimise seismicity in deep South African gold mines and their applicability to control coal bumps.
D. Malan, J. Napier
semanticscholar   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Liquidity Shocks and Order Book Dynamics [PDF]

We propose a dynamic competitive equilibrium model of limit order trading, based on the premise that investors cannot monitor markets continuously.
Biais, Bruno, Weill, Pierre-Olivier
core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

On Overborrowing [PDF]

This paper characterizes the equilibrium dynamics in an economy facing an aggregate debt ceiling. This borrowing limit is intended to capture an environment in which foreign investors base their lending decisions predominantly upon macro indicators ...
Martin Uribe
core  

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

How glasses explore configuration space

, 2002
We review a statistical picture of the glassy state derived from the analysis of the off-equilibrium fluctuation-dissipation relations. We define an ultra-long time limit where ``one time quantities'' are close to equilibrium while response and ...
, , , Barrat A, Barrat A, Barrat A, Barrat J L, Bellon L, Biroli G, Bouchaud J-P, Cardenas M, Cugliandolo L, Cugliandolo L F, Cugliandolo L F, Doliwa B, Franz S, Franz S, Franz S, Franz S, Grigera T S, Herisson D, Kurchan J, Marinari E, Montanari A, Mézard M, Mézard M, Mézard M, Nieuwenhuizen M Th, Norblad P, Onsager L, Onsager L, Onsager L, Parisi G, Parisi G, Parisi G, Parisi G, Parisi G, S Franz, Sellitto M, Stillinger F H, Struik L C E   +40 more
core   +1 more source