Results 61 to 70 of about 14,293 (184)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, Volume 13, Issue 35, 24 June 2026.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Validación del método LAL para determinar endotoxinas bacterianas en el inyectable heparina sódica

VacciMonitor, 2012
Dentro del control de la calidad de los productos farmacéuticos, la United State Pharmacopeia establece la cuantificación de endotoxinas bacterianas por el método de lisado de amebocito de Limulus , como monitor de pirógenos para más del 90% de los ...
Nancy Burguet, Lázaro César Brito
doaj  

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Endotoxin Contamination of Large Volume Parenterals as Detected by Limulus Amebocyte Lysate as an Alternative to Rabbit Pyrogen Test [PDF]

Journal of Sciences, Islamic Republic of Iran, 1989
The possibility of replacing the rabbit pyrogen test by the Limulus Amebocyte lysate (LAL) test, as a final release test for Large Volume Parenterals (LVPs) was investigated.
doaj  

Contamination of nanoparticles by endotoxin: evaluation of different test methods

Particle and Fibre Toxicology, 2012
Background Nanomaterials can be contaminated with endotoxin (lipopolysaccharides, LPS) during production or handling. In this study, we searched for a convenient in vitro method to evaluate endotoxin contamination in nanoparticle samples. We assessed the
Smulders Stijn, Kaiser Jean-Pierre, Zuin Stefano, Van Landuyt Kirsten L, Golanski Luana, Vanoirbeek Jeroen, Wick Peter, Hoet Peter HM   +7 more
doaj   +1 more source

Cerebrospinal fever, particularity of laboratory diagnosis

One Health & Risk Management, 2021
Introduction. Bacterial meningitis (BM) is a medical emergency. BM is the most common and notable infection of the central nervous system, can progress rapidly, and can result in death or permanent debilitation.
Guy SAPIR, Daniela COJOCARI
doaj  

Aplicabilidade do Teste de Ativação de Monócitos (MAT) no Brasil: importância da sua utilização como teste para detecção de pirogênios no controle da qualidade de produtos injetáveis

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2015
O MAT (sigla do inglês Monocyte Activation Test) é considerado um potencial substituto do Teste de Pirogênios, entretanto: i. não foi avaliado para um número suficiente de produtos; ii.
Cristiane Caldeira da Silva, Mayara Cruz, João Carlos Freitas, Octavio Presgrave, Aurea Moraes, Isabella Fernandes Delgado   +5 more
doaj   +1 more source

Limulus test

Citation: 'Limulus test' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13387 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Bioactivity and immunological evaluation of LPS from different serotypes of Helicobacter pylori

Iranian Journal of Microbiology, 2013
Background and Objectives: Helicobacter pylori is the causative agent of peptic ulcer disease and a co-factor in development of gastric malignancies. LPS are among toxic substances produced by H.
Davoud Esmaeilli, Ashraf Mohabati-Mobarez, Ali Hatef-Salmanian, Ahmad Zavaran-Hosseini   +3 more
doaj