Results 151 to 160 of about 4,929,883 (200)

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development. [PDF]

Cell Genom
Adami A, Garza R, Gerdes P, Johansson PA, Dorazehi F, Koutounidou S, Castilla-Vallmanya L, Atacho DAM, Sharma Y, Johansson JG, Tam O, Kirkeby A, Barker RA, Hammell MG, Douse CH, Jakobsson J.   +15 more
europepmc   +1 more source

Long-read genome and RNA sequencing resolve a pathogenic intronic germline LINE-1 insertion in APC. [PDF]

NPJ Genom Med
Baumann AA, Knol LI, Arlt M, Hutschenreiter T, Richter A, Widmann TJ, Franke M, Hackmann K, Winkler S, Richter D, Spier I, Aretz S, Aust D, Porrmann J, William D, Schröck E, Glimm H, Glimm H, Jahn A.   +18 more
europepmc   +1 more source

Long-read technologies identify a hidden LINE-1/ERV1 insertion in IQCB1 as causative variant for Senior-Løken syndrome. [PDF]

NPJ Genom Med
de Bruijn SE, Ingeborgh VDBL, Derks R, Haer-Wigman L, O'Gorman L, Cremers FPM, van Beek R, Hoischen A, Roosing S, Neveling K.   +9 more
europepmc   +1 more source

LINE-1 DNA methylation mediates smoking-related risk in site-specific urothelial carcinoma: a Taiwan case-control study. [PDF]

Arch Toxicol
Lin CH, Hung PH, Chang CH, Chang H, Chung MC, Chang WC, Chung CJ.   +6 more
europepmc   +1 more source

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

Adami A, Garza R, Gerdes P, Johansson PA, Dorazehi F, Koutounidou S, Castilla-Vallmanya L, Atacho DA, Sharma Y, Johansson JG, Tam O, Kirkeby A, Barker RA, Gale-Hammell M, Douse CH, Jakobsson J.   +15 more
europepmc   +1 more source

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LINE-1: a human transposable element

Gene, 1993
Among the 10(5) LINE-1 sequences (L1Hs) in the human genome are one or more 6-kb segments that are active retrotransposons. Expression of these retrotransposons appears to be favored in cells of germ line origin, as well as in some other tumor cells of epithelial origin.
M F, Singer, V, Krek, J P, McMillan, G D, Swergold, R E, Thayer   +4 more
openaire   +2 more sources

Undermethylation of specific LINE-1 sequences in human cells producing a LINE-1 -encoded protein

Gene, 1993
Nucleotide sequences near the 5' ends of some long interspersed elements-1 (LINE-1) from Homo sapiens (L1Hs) are undermethylated in cell lines which produce a L1Hs-encoded protein. In contrast, these sequences are methylated in cell lines with little or no detectable L1Hs expression.
R E, Thayer, M F, Singer, T G, Fanning
openaire   +2 more sources

Targeted cloning of a subfamily of LINE-1 elements by subfamily-specific LINE-1-PCR

Mammalian Genome, 1993
Subfamily-specific LINE-1 PCR (SSL1-PCR) is the targeted amplification and cloning of defined subfamilies of LINE-1 elements and their flanking sequences. The targeting is accomplished by incorporating a subfamily-specific sequence difference at the 3' end of a LINE-1 PCR primer and pairing it with a primer to an anchor ligated within the flanking ...
N C, Casavant, S C, Hardies
openaire   +2 more sources

LINE-1 Retrotransposition in the Nervous System

Annual Review of Cell and Developmental Biology, 2012
Long interspersed element-1 (LINE-1 or L1) is a repetitive DNA retrotransposon capable of duplication by a copy-and-paste genetic mechanism. Scattered throughout mammalian genomes, L1 is typically quiescent in most somatic cell types. In developing neurons, however, L1 can express and retrotranspose at high frequency.
Charles A, Thomas, Apuã C M, Paquola, Alysson R, Muotri   +2 more
openaire   +2 more sources

การเปลี่ยนแปลงของระดับเมธิลเลชั่นของ LINE-1 ในมะเร็งระหว่างที่มีการแพร่กระจาย

ที่มาและปัญหา: มะเร็งหลายชนิดนั้นมักพบการลดลงของระดับเมธิลเลชั่นของลำดับซ้ำ LINE-1 เมื่อเปรียบเทียบกับในเซลล์ปกติโดยเฉพาะในมะเร็งที่มีการพัฒนาอย่างเป็นลำดับขั้น จึงมีความน่าสนใจว่าการเกิดการลดลงของระดั บเมธิลเลชั่นของ LINE-1 นั้นอาจจะมีความเกี่ยวข้องกับกลไกการแพร่กระจายของมะเร็งที่มีการพัฒนาของเซลล์มะเร็งอย่างเป็นลำดับขั้น วัตถุประสงค์:เปรียบเทียบระด ...
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