Results 131 to 140 of about 28,196,398 (315)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Key Points in Line Splitting for Hangzhou Metro Line 1 Linping Branch
Chengshi guidao jiaotong yanjiuObjectiveThe splitting and renovation construction of metro operating lines is a highly complex task that involves multiple professional disciplines and challenges related to compatibility between new and existing systems. Such projects are characterized
Zhiming SUN
doaj +1 more source
, 2018 The County Line was a public, informational publication of the Toledo Lucas County Public Library. The first issue came out in March 1970, and it continued until December 1992.
Toledo Lucas County Public Library
core
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
, 2018 The County Line was a public, informational publication of the Toledo Lucas County Public Library. The first issue came out in March 1970, and it continued until December 1992.
Toledo Lucas County Public Library
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
, 2018 The County Line was a public, informational publication of the Toledo Lucas County Public Library. The first issue came out in March 1970, and it continued until December 1992.
Toledo Lucas County Public Library
core
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
X-ray narrow line region variability as a geometry probe : the case of NGC 5548
, 2009 We study the long time scale variability of the gas responsible for the X-ray narrow emission lines in the Seyfert 1 galaxy NGC 5548, in order to constrain the location and geometry of the emitting gas.
Astrophysics +8 more
core +1 more source