Results 121 to 130 of about 28,196,398 (315)

LINE-1 DNA methylation: A potential forensic marker for discriminating monozygotic twins

, 2015
Discriminating individuals within a pair of monozygotic (MZ) twins using genetic markers remains unresolved. This inability causes problems in criminal or paternity cases involving MZ twins as suspects or alleged fathers.
Xiaojing Zhang (163406), Jie Xu (34477), Lina Yan (5883473), Lihong Fu (12967104), Jeffrey Craig (13065240), Shujin Li (313783), Bin Cong (313785), Guangping Fu (13616719), Chunling Ma (313780)   +8 more
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Development and Validation of a Machine Learning COVID-19 Veteran (COVet) Deterioration Risk Score

Critical Care Explorations
BACKGROUND AND OBJECTIVE:. To develop the COVid Veteran (COVet) score for clinical deterioration in Veterans hospitalized with COVID-19 and further validate this model in both Veteran and non-Veteran samples.
Sushant Govindan, MD, MSc, Alexandra Spicer, MS, Matthew Bearce, MPS, Richard S. Schaefer, PharmD, Andrea Uhl, BA, Gil Alterovitz, PhD, Michael J. Kim, MD, Kyle A. Carey, MPH, Nirav S. Shah, MD, MPH, Christopher Winslow, MD, Emily Gilbert, MD, Anne Stey, MD, MSc, Alan M. Weiss, MD, Devendra Amin, MD, George Karway, PhD, Jennie Martin, MS, Dana P. Edelson, MD, Matthew M. Churpek, MD, MPH, PhD   +17 more
doaj   +1 more source

Evolutionary product line requirements engineering

, 2022
S.319Product Line Engineering has a widespread use in industry now. Therefore there is a high need for customizable, adaptable, and also for mature methods. Scoping and product line analysis are a unique and integral part of Product Line Engineering.
Barreto Villela, Karina, John, Isabel
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Experimental investigation of productivity and surface integrity features in trim cut WEDM operation of hybrid metal matrix composite

International Journal of Lightweight Materials and Manufacture
Present study is focused on optimization of WEDM process parameters for increased productivity and improved surface quality of the machined surface of hybrid composite [Al6061 (90 %), SiC (2.5 %) and TiB2 (7.5 %)] by utilizing the trim cut strategy ...
Nilesh Kumar, Jatinder Kumar
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source